Priyanka Chauhan

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BACKGROUND  Low iron availability in the host upregulates the mbt gene cluster of Mycobacterium tuberculosis, which is responsible for mycobactin biosynthesis. However, the biological significance of mycobactins in the growth of this pathogen and in disease progression has not been elucidated. METHODS  We have disrupted the mbtE gene (Rv2380c) in the mbt(More)
By employing modified Cornell model, we have evaluated the potential of adjunctive immunotherapy with DNA vaccines to shorten the tuberculosis chemotherapy period and reduce disease reactivation. We demonstrate that α-crystallin based DNA vaccine (DNAacr) significantly reduced the chemotherapy period from 12 weeks to 8 weeks when compared with the(More)
BACKGROUND The failure of Mycobacterium bovis Bacille Calmette-Guérin to impart satisfactory protection against adult pulmonary tuberculosis has necessitated the development of more effective TB vaccines. The assumption that the vaccine strain should be antigenically as similar as possible to the disease causing pathogen has led to the evaluation of(More)
Mycoplasma pneumoniae is a common cause of respiratory infections in humans. Although it is usually associated with mild acute respiratory infections such as sore throat, pharyngitis, rhinitis and tracheobronchitis. The aim of this study was to evaluate the prevalence of M. pneumoniae among the patients of respiratory tract infection (RTI) in hospitalized(More)
DPSO-FOHA I and DPSO-FOHA II algorithms, based on multilevel thresholding are proposed in this paper. Optimal multilevel thresholds for colored images are maximized by using Otsu's between class variance functions. The Darwinian principle has been used to improve the value of fitness function along with the concept of fractional calculus, which optimizes it(More)
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