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Magnetic resonance imaging (MRI) patterns were examined together with cerebrospinal fluid (CSF) biomarkers in serial scans of Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with mild cognitive impairment (MCI). The SPARE-AD score, summarizing brain atrophy patterns, was tested as a predictor of short-term conversion to Alzheimer's disease(More)
This paper presents a general methodology for high-dimensional pattern regression on medical images via machine learning techniques. Compared with pattern classification studies, pattern regression considers the problem of estimating continuous rather than categorical variables, and can be more challenging. It is also clinically important, since it can be(More)
Different inflammatory and metabolic pathways have been associated with Alzheimeŕs disease (AD). However, only recently multi-analyte panels to study a large number of molecules in well characterized cohorts have been made available. These panels could help identify molecules that point to the affected pathways. We studied the relationship between a panel(More)
In this paper we present a novel label fusion algorithm suited for scenarios in which different manual delineation protocols with potentially disparate structures have been used to annotate the training scans (hereafter referred to as "atlases"). Such scenarios arise when atlases have missing structures, when they have been labeled with different levels of(More)
Increased interest in web-based education has spurred the proliferation of online learning environments. However, these platforms suffer from high dropout rates due to lack of sustained motivation among the students taking the course. In an effort to address this problem, we propose an incentive-based, instructor-driven approach to orchestrate the(More)
In this paper we present a method to segment four brainstem structures (midbrain, pons, medulla oblongata and superior cerebellar peduncle) from 3D brain MRI scans. The segmentation method relies on a probabilistic atlas of the brainstem and its neighboring brain structures. To build the atlas, we combined a dataset of 39 scans with already existing manual(More)
To use International Classification of Disease Codes (ICD-9) codes to investigate primary immune deficiency (PID) in New York State. We investigated the diagnosis of Primary Immune Deficiency (PID) in New York State (NYS) using the Statewide Planning and Research Cooperative System (SPARCS) database, a comprehensive data reporting system that collects ICD-9(More)
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