Priya Makhijani

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Metallothioneins (MT) are ubiquitous, low-molecular-weight proteins that exhibit high binding affinities for heavy metal ions. The expression of these cysteine-rich proteins is induced in response to various types of chemical and physical stresses and therefore can be used to assess human exposure to cytotoxic environmental agents. In the current study, MT(More)
Previously, we have shown the loss of anti-Bax function in Creutzfeldt Jakob disease (CJD)-associated prion protein (PrP) mutants that are unable to generate cytosolic PrP (CyPrP). To determine if the anti-Bax function of PrP modulates the manifestation of prion diseases, we further investigated the anti-Bax function of eight familial(More)
E. coli strains show low sensitivity to ultraviolet-A (UV-A) irradiation, a common method of decontamination. The two known catalases in E. coli, hydroperoxidase I (HPI) and hydroperoxidase II (HPII) are suspected to protect against UV-A inactivation by removing destructive reactive oxygen species (ROS). Catalase HPI knockout UM197 cells, subjected to UV-A,(More)
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