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OBJECTIVES To delineate the role of capsaicin (8-methyl-N-vanillyl-6-nonenamide) as an inhibitor of the NorA efflux pump and its impact on invasion of macrophages by Staphylococcus aureus. METHODS Capsaicin in combination with ciprofloxacin was tested for activity against S. aureus SA-1199B (NorA overproducing), SA-1199 (wild-type) and SA-K1758 (norA(More)
With the expansion of the Internet and World Wide Web (or the Web), research environments have changed dramatically. As a result, the need to be able to efficiently and securely access information and resources from remote computer systems is becoming even more critical. This paper describes the development of an extendable integrated Web-accessible(More)
In this study, we investigated the role of autophagy induced by boswellic acid analog BA145 on cell cycle progression in pancreatic cancer cells. BA145 induced robust autophagy in pancreatic cancer cell line PANC-1 and exhibited cell proliferation inhibition by inducing cells to undergo G2/M arrest. Inhibition of G2/M progression was associated with(More)
In modern drug discovery, virtual screening is an attractive and cost-effective approach, which is widely applied to filter chemical compound libraries for the identification of novel inhibitors. Epidermal growth factor receptor protein is a well reported anticancer molecular target due to its over expression and mutation in many solid tumours. The decline(More)
Energy consumption in commercial buildings is tremendous, resulting in significant monetary cost and waste of natural resources. Designing a low-cost system that serves the goal of saving energy while not forcing people to compromise their personal comfort is important for future smart commercial buildings. Proactive energy saving actions from users in the(More)
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