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A mobilizable suicide vector, pSUP5011, was used to introduce Tn5-mob in a new facultative sulfur lithotrophic bacterium, KCT001, to generate mutants defective in sulfur oxidation (Sox(-)). The Sox(-) mutants were unable to oxidize thiosulfate while grown mixotrophically in the presence of thiosulfate and succinate. The mutants were also impaired in(More)
Expression of profilin-1 (Pfn1) is downregulated in breast cancer cells, the functional significance of which is yet to be understood. To address this question, in this study we evaluated how perturbing Pfn1 affects motility and invasion of breast cancer cells. We show that loss of Pfn1 expression leads to enhanced motility and matrigel invasiveness of(More)
Differential cell adhesive properties are known to regulate important developmental events like cell sorting and cell migration. Cadherins and protocadherins are known to mediate these cellular properties. Though a large number of such molecules have been predicted, their characterization in terms of interactive properties and cellular roles is far from(More)
Differentiated tissues may be considered as materials with distinct properties. The differentiation program of a given tissue ensures that it acquires material properties commensurate with its function. It may be hypothesized that some of these properties are acquired through production of tissue-specific metabolites synthesized by metabolic enzymes. To(More)
—Psoriasis is a chronic inflammatory human skin disorder characterized by T-cell mediated hyperproliferation of Keratinocytes. The exact nature of the triggering agent of psoriasis is not yet known. Cell biological findings on the disease revealed that Helper T-cells in the human blood as well as Dendritic Cells play an important role in inflicting the(More)
—Drug therapy response of HIV-1 infected immune system is an important area of research by now. Today, a greater knowledge of drug induced CTL response allows us to better understand of cell mediated immune mechanism and humoral immune mechanism for viral infections. Moreover excessive stimulation of CTL in the immune system by different drugs leads to(More)
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