Prithvi M Mohan

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Botulinum neurotoxins (types A and B), which are microbial proteins consisting of two disulfide-linked chains, inhibit specifically and with high potency the release of acetylcholine from peripheral nerve terminals. As a prerequisite for a long-term development of effective treatments for botulism, the internalization and inhibitory action of the toxin and(More)
The urokinase-type plasminogen activator (uPA) and uPA receptor (UPAR) play important roles in the proteolytic cascade involved in the invasiveness of gliomas and other invasive tumors. High-level expression of uPAR has been correlated with high-grade glioma cell lines and tumors We report here that down-regulating uPAR levels by antisense strategy using an(More)
  • S S Lakka, R Rajagopal, +10 authors J S Rao
  • 2001
The urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in the proteolytic cascade involved in the metastasis of lung and other cancers. We report that the reduction in uPAR levels produced by an antisense strategy using an adenovirus construct (Ad-uPAR) in H1299 cells, an invasive human lung cancer cell line that(More)
During the development of behavioral tolerance to the organophosphate monocrotophos, the activities of AChE and BuChE and the content of ACh were affected in different brain areas of male albino rats. The inhibition of AChE and BuChE activities and the elevation of ACh content were progressive till 7 days and were followed by a recovery trend towards(More)
HYPOTHESIS p21-activated kinase (PAK) regulates signaling pathways that promote cell survival and proliferation; therefore, pharmacological inhibition of PAK will induce cell death in vestibular schwannomas (VS) and meningiomas. BACKGROUND All VS and many meningiomas result from loss of the neurofibromatosis type 2 (NF2) gene product merlin, with ensuing(More)
Electrical recordings made from the peripheral nerves of the 7th abdominal ganglion in the scorpion, H. fulvipes showed pronounced activity on ipsilateral stimulation of the connective and minimum activity on the contralateral side. Measurement of conduction velocities and synaptic delays indicated that ipsilateral pathways are probably monosynaptic and(More)
Periplaneta americana were subjected to unilateral transection of the ventral nerve cord, and the levels of soluble and total proteins and total carbohydrates were determined 30 days postoperatively. Total proteins showed a decrease while soluble proteins and total carbohydrates showed an elevation. These changes were correlated with the generation of giant(More)
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