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The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation. Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for(More)
Purpose: The inhibitor of apoptosis proteins (IAP) are overexpressed in hormone-refractory prostate cancer, rendering the cancer cells resistant to radiation. This study aims to investigate the radiosensitizing effect of small-molecule IAP inhibitor both in vitro and in vivo in androgenindependent prostate cancer and the possible mechanism of(More)
It seems clear that androgen receptor (AR)–regulated expression of the TMPRSS2:ERG fusion gene plays an early<lb>role in prostate cancer (PC) development or progression, but<lb>the extent to which TMPRSS2:ERG is down-regulated in response to androgen deprivation therapy (ADT) and<lb>whether AR reactivates TMPRSS2:ERG expression in castra-<lb>tion-resistant(More)
TITLE: Deficient BIM Expression as a Mechanism of Intrinsic and Acquired Resistance to Targeted Therapies in EGFR-Mutant and ALK-Positive Lung Cancers PRINCIPAL INVESTIGATOR: Lecia Sequist MD. CONTRACTING ORGANIZATION: Massachusetts General Hospital Boston, MA 02114 REPORT DATE: August 2015 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and(More)
s and Conference Proceedings: 1. Kluge JA, Martin JT, Nerurkar NL, Amaniera FA, Pampati RA, Elliott DM, Mauck RL (2010). Functional enhancement of disc-like angle-ply structures via dynamic culture, 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, USA (Poster Presentation) 2. Elliott DM, Nerurkar NL, Huang AH, Kluge JA, Smith LJ, Martin(More)