Primož Kovačič

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This report demonstrates that ease of electron uptake by 1-methyl-4-phenylpyridinium (MPP+), apparently the active agent derived from MPTP, is influenced by conformation of the phenyl ring. From quantum mechanical calculations on MPP+, electron affinity is most negative for the nearly coplanar arrangement, indicating that the molecule is most readily(More)
Kibera (edge region within the Nairobi) is the biggest informal settlement in Kenya, and one of the biggest in Africa. The population estimates vary between 170,000 and 1 million and are highly debatable. What is certain is that the area is large (roughly 2.5 km2), host at least hundreds of thousands people, is informal and self-organized, stricken by(More)
Cyclic voltammetry data were obtained for eight phenazines and phenazine-N-oxides, and eleven quinoxalines and quinoxaline-N-oxides: 1,6-phenazine-diol-5,10-dioxide (iodinin), iodinin copper complex, 6-methoxy-1-phenazinol-5,10-dioxide 1,6-dimethoxyphenazine-5-oxide, 1,6-phenazinediol, 1,6-dimethoxyphenazine, quinoxaline-1,4-dioxide,(More)
A mechanism of action is proposed that encompasses almost all of the main categories of antimalarial agents: quinones and precursors, dapsone metabolites, metal complexes of thiosemicarbazones and biguanides, iminium-type ions from acridines and quinolines, and peroxides. The toxic effect of the drugs is believed to result from the generation of reactive(More)
The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm. Electrochemical studies were performed with some of the main types of agents: iminium ions (adenine iminium from alkylating species, iminium metabolite of 6-mercaptopurine, nitidine, other polynuclear(More)
Electrochemical data were acquired for several categories of anthelmintic agents, namely, iminium-type ions, metal derivatives and chelators, quinones and iminoquinones, and nitroheterocycles. Reductions usually were in the favorable range of +0.2 to -0.7 V versus normal hydrogen electrode. The drug effect is believed to result in part from either the(More)
This report examines the mechanism of action of DNA-binding anticancer drugs that involve electron transfer and oxidative stress, and primarily focuses on neglected issues surrounding molecular electrostatic potentials (MEP), the energetics of initial guanine oxidation and the consequences of the sequence dependence of DNA structure on electron transport(More)
Most of the main categories of bactericidal agents, namely, aliphatic and heterocyclic nitro compounds, metal derivatives and chelators, quinones, azo dyes, and iminium-type ions, are proposed to exert their action by a unified mechanism. The toxic effect is believed to result generally from the catalytic production of reactive oxygen radicals that usually(More)
Cyclic voltammetry data were obtained for various 2,3-disubstituted quinoxaline di-N-oxides: dimethyl, bishydroxymethyl, bisacetoxymethyl, bis-N-anilinomethyl, and dicarboxaldehyde hydrate. The dimethyl derivative exhibited the most negative E1/2 value, and along with the diol, showed reversible reduction for the first wave. Rationalizations of the E1/2(More)
Evidence is presented in support of an electron transfer mechanism for various metal complexes possessing anti-neoplastic properties. Cyclic voltammetry was performed on several metallocenes, bis(acetato)bis(imidazole)Cu(II), and coordination compounds (Cu or Fe) of the antitumor agents, bipyridine, phenanthroline, hydroxyurea, diethyldithiocarbamate, and(More)