Prerna Banati

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Pharmacokinetics (PK) of xenobiotics can differ widely between children and adults due to physiological differences and the immaturity of enzyme systems and clearance mechanisms. This makes extrapolation of adult dosimetry estimates to children uncertain, especially at early postnatal ages. While there is very little PK data for environmental toxicants in(More)
This paper reviews existing data on the variability in parameters relevant for health risk analyses. We cover both exposure-related parameters and parameters related to individual susceptibility to toxicity. The toxicity/susceptibility data base under construction is part of a longer term research effort to lay the groundwork for quantitative distributional(More)
A significant data base has been assembled on human variability in parameters representing a series of steps in the pathway from external exposure to the production of biological responses: contact rate (e.g., breathing rates/body weight, fish consumption/body weight); uptake or absorption (mg/kg)/intake or contact rate; general systemic availability net of(More)
Part of the explanation for the persistent epidemiological findings of associations between mortality and morbidity with relatively modest ambient exposures to airborne particles may be that some people are much more susceptible to particle-induced responses than others. This study assembled a database of quantitative observations of interindividual(More)
Policy Forum T here have been signifi cant increases in development fi nance since 2000, particularly for health [1,2]. As country programs put this money to work, important lessons and challenges on how to make health fi nance more effective emerge. Performance-based funding provides clear incentives to achieve results and has been used by organizations(More)
a Global Fund to fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland. b University of the Mediterranean, INSERM/IRD Research Unit 912 SE4S, Marseille, France. Correspondence to Jean-Paul Moatti (e-mail: moatti@marseille.inserm.fr). doi:10.2471/BLT.07.049361 According to the Organisation for Economic Co-operation and Development, the health sector has(More)
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