Predrag Bursac

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The osteoinductivity of demineralized bone matrix (DBM) varies from donor to donor as a result of varying levels of multiple growth factors, matrix integrity, and artifacts from material processing. Many in vitro assays are currently used for screening the osteoinductivity of DBM. The objectives of this study were to determine the correlation of specific(More)
BACKGROUND Although the use of meniscal allografts to replace severely damaged or absent menisci is commonplace, little is known about the effects of donor age on the biochemical and biomechanical properties of human menisci. HYPOTHESIS The mechanical and biochemical properties of human medial and lateral menisci from donors less than 45 years of age do(More)
The menisci of the knee play a significant role in the complex biomechanics of the joint and are critically important in maintaining articular cartilage health. While a general form-function relationship has been identified for the structural orientation of the extra-cellular matrix of the meniscus, the role of individual biochemical components has yet to(More)
This study was conducted to determine if a novel cleaning process could extract antigenic material from bovine bone thereby improving incorporation. Cleaned bovine xenograft, untreated bovine xenograft and sheep allograft were implanted into the tibia of mature sheep for 12 and 24 weeks. Inflammation, bone integration and immunological reactions were(More)
Introduction: Meniscus allograft transplantation (MAT) has gained popularity in reducing pain and restoring normal joint function following meniscectomy1. Similarly to other allograft tissues, meniscus allografts may carry the risk of disease transmission if the tissue cannot be sterilized. The BioCleanse® sterilization process is a low-temperature chemical(More)
OBJECTIVES: We previously demonstrated that diaspirin crosslinked hemoglobin (DCLHb, Baxter Healthcare Corp.) improves systemic oxygen uptake in sepsis. Therefore, our objective was to study the effects of DCLHb on microcirculatory blood flow in septic rats. DESIGN: Prospective and randomized experimental study in a university-affiliated laboratory.(More)
The use of electron microscope in the study of the diseased skin of four patients with Alopecia areata has detected changes in the endothelial cells with narrowed capillary lumen. The authors have brought these findings in connection with the decreased blood circulation in lesions of patients with Alopecia areata which necessiates the use of vasodilatator(More)
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