Preben Kjølhede

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The purpose of this retrospective study was to evaluate the importance of different preoperative estimates and postoperative complications on the outcome of the Burch colposuspension with respect to urinary continence. During the period 1980-1988 243 women were operated upon with the Burch colposuspension for stress incontinence or mixed incontinence. The(More)
BACKGROUND Fast-track regimen has been shown to reduce postoperative complications in gastrointestinal surgery. AIMS We investigated the incidence and type of postoperative complications and associated risk factors after benign abdominal hysterectomy undertaken in a fast-track program. METHODS A prospective longitudinal cohort study. In five Swedish(More)
OBJECTIVE To determine whether postoperative symptoms differ between women who undergo abdominal benign hysterectomy in a fast-track model under general anesthesia or spinal anesthesia with intrathecal morphine. DESIGN Secondary analysis from a randomized, open, multicenter study. SETTING Five hospitals in south-east Sweden. POPULATION One-hundred and(More)
Adipose tissue is a primary target of insulin, but knowledge about insulin signalling in human adipocytes is limited. We developed an electroporation technique for transfection of primary human adipocytes with a transfection efficiency of 15% +/- 5 (mean +/- S.D.). Human adipocytes were co-transfected with a mutant of IRS-3 (all four potential PI3-kinase(More)
OBJECTIVE We studied the activity and regulation of the peroxisome proliferator-activated receptor-gamma response element (PPRE) in primary human adipocytes. METHODS We transfected primary human adipocytes with a plasmid-encoding firefly luciferase cDNA under control of a PPRE from the acyl-coenzyme A oxidase gene by using our newly developed(More)
OBJECTIVES To evaluate the associations between maternal age and obstetric and neonatal outcomes in primiparous women with emphasis on teenagers and older women. DESIGN A population-based cohort study. SETTING The Swedish Medical Birth Register. PARTICIPANTS Primiparous women with singleton births from 1992 through 2010 (N=798,674) were divided into(More)
OBJECTIVE To determine the long-term objective and subjective outcomes of use of a porcine skin graft (Pelvicol) compared with conventional colporrhaphy in recurrent pelvic organ prolapse surgery and to analyze risk factors and safety. DESIGN Open randomized controlled multicenter study. SETTING Eight Swedish hospitals. POPULATION 135 consecutive(More)
OBJECTIVE To determine whether the day-by-day postoperative recovery differs between women undergoing subtotal and total abdominal hysterectomy, and to analyse factors associated with postoperative recovery and sick leave. DESIGN A prospective, open, randomised multicentre trial. SETTING Seven hospitals and one private clinic in the south-east of(More)
OBJECTIVE To determine if maternal age (35 years of age or older) in primiparous women is a risk factor for the development of obstetric anal sphincter rupture (OASR) and to identify obstetric factors associated with it. MATERIAL AND METHODS This is a retrospective case-control study. The study population was made up of the 5,345 primiparous women aged(More)
OBJECTIVE To evaluate whether vaginal cleansing reduces the risk of postoperative infection after abdominal total hysterectomy on benign indications and to analyze risk factors. DESIGN Retrospective cohort study. SETTING All clinics including patients in the Swedish National Register for Gynecological Surgery. POPULATION All 7,193 women who underwent(More)