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Proteolysis of Human Thrombin Generates Novel Host Defense Peptides
The coagulation system is characterized by the sequential and highly localized activation of a series of serine proteases, culminating in the conversion of fibrinogen into fibrin, and formation of aExpand
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Structure-Activity Studies and Therapeutic Potential of Host Defense Peptides of Human Thrombin
ABSTRACT Peptides of the C-terminal region of human thrombin are released upon proteolysis and identified in human wounds. In this study, we wanted to investigate minimal determinants, as well asExpand
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C-terminal Peptides of Tissue Factor Pathway Inhibitor Are Novel Host Defense Molecules*
Tissue factor pathway inhibitor (TFPI) inhibits tissue factor-induced coagulation, but may, via its C terminus, also modulate cell surface, heparin, and lipopolysaccharide interactions as well asExpand
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Host Defense Peptides of Thrombin Modulate Inflammation and Coagulation in Endotoxin-Mediated Shock and Pseudomonas aeruginosa Sepsis
Gram-negative sepsis is accompanied by a disproportionate innate immune response and excessive coagulation mainly induced by endotoxins released from bacteria. Due to rising antibiotic resistance andExpand
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Proteolytic Activation Transforms Heparin Cofactor II into a Host Defense Molecule
The abundant serine proteinase inhibitor heparin cofactor II (HCII) has been proposed to inhibit extravascular thrombin. However, the exact physiological role of this plasma protein remainsExpand
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Replication-competent Ad11p vector (RCAd11p) efficiently transduces and replicates in hormone-refractory metastatic prostate cancer cells.
Selective replication-competent adenovirus serotype 5 vectors have been used for prostate cancer therapy. Unfortunately, gene transfer is inefficient because hormone-refractory metastatic prostateExpand
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A fibrin biofilm covers blood clots and protects from microbial invasion
Hemostasis requires conversion of fibrinogen to fibrin fibers that generate a characteristic network, interact with blood cells, and initiate tissue repair. The fibrin network is porous and highlyExpand
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Antimicrobial activity of peptides derived from human ß-amyloid precursor protein.
Antimicrobial peptides are important effector molecules of the innate immune system. Here, we describe that peptides derived from the heparin-binding disulfide-constrained loop region of humanExpand
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An antimicrobial helix A-derived peptide of heparin cofactor II blocks endotoxin responses in vivo.
Host defense peptides are key components of the innate immune system, providing multi-facetted responses to invading pathogens. Here, we describe that the peptide GKS26 (GKSRIQRLNILNAKFAFNLYRVLKDQ),Expand
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The C-Terminal Sequence of Several Human Serine Proteases Encodes Host Defense Functions
Serine proteases of the S1 family have maintained a common structure over an evolutionary span of more than one billion years, and evolved a variety of substrate specificities and diverse biologicalExpand
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