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Transcriptional profiles of CD133+ and CD133- glioblastoma-derived cancer stem cell lines suggest different cells of origin.
Comparing CSC lines with their putative cells of origin, the data suggest that the heterogeneous tumor entity GBM may derive from cells that have preserved or acquired properties of either fNSC or aNSC but lost the corresponding differentiation potential.
The cancer stem cell subtype determines immune infiltration of glioblastoma.
It is shown that TGF-beta regulates proliferation, migration, and tumorigenicity of mesenchymal GBM cancer stem cells (CSCs) in vivo and in vitro, and that the molecular subtype of CSCs T GF-beta-dependently contributes to the degree of immune infiltration.
Production and characterization of a camelid single domain antibody-urease enzyme conjugate for the treatment of cancer.
- B. Tian, W. Wong, E. Hegmann, K. Gaspar, Praveen Kumar, H. Chao
- Biology, ChemistryBioconjugate chemistry
- 14 May 2015
A novel immunoconjugate (L-DOS47) was developed and characterized as a therapeutic agent for tumors expressing CEACAM6 and is being investigated as a potential therapeutic agent in human phase I clinical studies for nonsmall cell lung cancer.
Integrative Analysis to Identify Genes Associated with Stemness and Immune Infiltration in Glioblastoma
Interestingly, EOMES was found to be very significantly involved in stemness and immunology and it was positively correlated to CXCR4, and BDNF, which was significant in methylation, was negatively correlated to BIRC5.
Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs.
Emerging Importance of Survivin in Stem Cells and Cancer: the Development of New Cancer Therapeutics
- Neerada Meenakshi Warrier, P. Agarwal, Praveen Kumar
- BiologyStem Cell Reviews and Reports
- 20 July 2020
The expression of survivin in normal and cancer cells is analyzed with a particular focus on its expression in cancer stem cell compartment and the challenges involving the development of potent and specific survivin inhibitors for cancer therapeutics are discussed.
CD24 and Nanog expression in Stem Cells in Glioblastoma: Correlation with Response to Chemoradiation and Overall Survival
- P. Soni, S. Qayoom, Rakesh K. Gupta
- Medicine, BiologyAsian Pacific journal of cancer prevention…
- 1 August 2017
An overexpression of CD24 by more than two fold was associated with poor overall survival in GBM and targeted therapy inclusive of drugs targeting stem cells directly or indirectly may be a promising therapeutic option.
HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells.
It is shown that high-mobility group AT hook 2 (HMGA2), a nonhistone chromosomal-binding protein, is highly and preferentially expressed in HSCs and in the most immature progenitor cell subset of fetal, neonatal, and adult human hematopoiesis.
Impaired TGF-β induced growth inhibition contributes to the increased proliferation rate of neural stem cells harboring mutant p53.
- Praveen Kumar, U. Naumann, L. Aigner, Joerg Wischhusen, C. Beier, D. Beier
- BiologyAmerican journal of cancer research
- 15 October 2015
The data suggest that the TGF-beta induced growth arrest in NPC depends on functional p53, and Mutational inactivation of p53 hence contributes to increased proliferation of NPC and likely to the formation of hyperplasia of the SVZ observed in p53 deficient mice in vivo.
Transient inhibition of NF-κB signaling enhances ex vivo propagation of human hematopoietic stem cells
- Mehrnaz Safaee Talkhoncheh, Agatheeswaran Subramaniam, M. Magnusson, Praveen Kumar, J. Larsson, Aurélie Baudet
- Biology, MedicineHaematologica
- 7 June 2018
It is shown that chemical inhibition of the NF-κB signaling pathway leads to a significant improvement of hematopoietic stem cell function from ex vivo cultured human umbilical cord blood derived CD34+ cells.