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Polarity of the microtubule (MT) cytoskeleton is essential for many cell functions. Cytoplasmic linker-associated proteins (CLASPs) are MT-associated proteins thought to organize intracellular MTs and display a unique spatiotemporal regulation. In migrating epithelial cells, CLASPs track MT plus ends in the cell body but bind along MTs in the lamella. In(More)
The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here we present a draft map of the human proteome using high-resolution Fourier-transform mass spectrometry. In-depth proteomic profiling(More)
Regulation of microtubule dynamics is essential for many cell biological processes and is likely to be variable between different subcellular regions. We describe a computational approach to analyze microtubule dynamics by detecting growing microtubule plus ends. Our algorithm tracked all EB1-EGFP comets visible in an image time-lapse sequence allowing the(More)
We explain why adverse asset shocks after good economic times lead to a sudden drying-up of liquidity. Financial firms raise short-term debt to finance asset purchases; this induces risk-shifting when economic conditions worsen and limits their ability to roll over debt. Constrained firms de-lever by selling assets to lower-leverage firms. In turn,(More)
As consumer electronic devices become more powerful and networked, users are required to understand more and more `complex' device functionalities just to carry out simplest tasks. Users are experiencing more and more inconvenience and frustration as the number and complexity of home devices rise and the amount of content/data stored in the home increases.(More)
This paper presents an approach of fusing the information provided by visible spectrum video with that of thermal infrared video to tackle video processing challenges such as object detection and tracking for increasing the performance and robustness of the surveillance system. An enhanced object detection strategy using gradient information along with(More)
BACKGROUND Although newborn screening for critical congenital heart disease (CCHD) was recommended by the US Health and Human Services Secretary's Advisory Committee on Heritable Disorders in Newborns and Children to promote early detection, it was deemed by the Secretary of the HHS as not ready for adoption pending an implementation plan from HHS agencies.(More)
Target Tracking as it moves through a sensor network has become an increasingly important application in Wireless Sensor Networks. This paper examines some of the target tracking techniques in use today. An analysis of each technique is presented along with it advantages, problems and possible improvements. There are seven main categories explored in this(More)