Pratik Saha

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The purpose of this study was to explore approaches to more accurately assess Caco-2 permeability of poorly water-soluble new chemical entities (NCEs) in an effort to determine their biopharmaceutics classification system (BCS) permeability class with a higher level of confidence. The transport of reference compounds and NCEs (Sch-Y, Sch 56592) was studied(More)
The purpose of this study was to evaluate the effects of solubilizing excipients on Caco-2 transport parameters of poorly water-soluble NCEs (new chemical entities), and determine their permeability class under the BCS guidance (Biopharmaceutics Classification System). The effect of solubilizing excipients on soluble donor concentration of Sch 56592, Sch-X(More)
Sodium alginate (SA) and gelatine (G) based hydrogels for biomedical applications, such as wound dressing, were crosslinked by calcium chloride (CaCl2) or glutaraldehyde (GTA) in order to overcome their exudates solubility. Swelling behaviour of prepared hydrogels in phosphate buffered saline with different pH value at 37 ° C was compared. It was proved(More)
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