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The role and modulation of autophagy in experimental models of myocardial ischemia-reperfusion injury
TLDR
Targeted modulation of this evolutionarily conserved intracellular cleansing autophagy mechanism, by targeted modulation through, among others, mammalian target of rapamycin (mTOR) inhibitors, adenosine monophosphate-activated protein kinase (AMPK) modulators, calcium lowering agents, resveratrol, longevinex, sirtuin activators, and lysosome inhibitors, may confer resistance to heart cells against I/R induced cell death. Expand
Dilemmas in end-stage heart failure
TLDR
Ethical dilemmas in end-stage HF are numerous, embroiling not only the patient, but also the caregiver, healthcare team, and society, creating a substantial strain on the healthcare system. Expand
Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease
TLDR
Klotho proteins are expressed in human cardiomyocytes for the first time and cardiac expression of Klotho is down-regulated in higher cardiovascular risk patients, while expression of stress-related molecules were significantly increased. Expand
Mechanisms of myocardial ischemia-reperfusion injury and the cytoprotective role of minocycline: scope and limitations.
TLDR
An overview of the major mechanisms involved in myocardial ischemia-reperfusion injury is presented, followed by an analysis of the mechanisms by which minocycline exerts its cytoprotective role and of studies that have been conducted in order to analyze minocyCline. Expand
Current Strategies in the Evaluation and Management of Cocaine-Induced Chest Pain
TLDR
The purpose of this review is to summarize the understanding of cocaine’s cardiovascular pathophysiology and to examine the current approach for proper evaluation and management of CCP. Expand
Cardioprotective Utility of Urocortin in Myocardial Ischemia- Reperfusion Injury: Where do We Stand?
TLDR
An updated review largely focused on the various mechanisms through which urocortin alters cellular metabolism is presented, and the clinical potential of uroc Cortin's cardioprotective ability in myocardial ischemia-reperfusion injury is discussed. Expand
Diagnostic Approach to Myocarditis Mimicking Myocardial Infarction at Initial Presentation
TLDR
The indications of myocardial biopsy are discussed, the relative utility of cardiac magnetic resonance imaging in formulating the diagnosis ofMyocarditis is compared and the relative Utility of Cardiac magnetic resonance Imaging is compared. Expand