Prasad Venugopal

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Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are haematological disorders that are characterised by the aberrant proliferation of abnormal myeloblasts in the bone marrow and the inability of these cells to differentiate into mature myeloid cells. Both are largely sporadic diseases; however, rare familial cases have been described.(More)
Heterozygous GATA2 mutations underlie an array of complex hematopoietic and lymphatic diseases. Analysis of the literature reporting three recurrent GATA2 germline (g) mutations (gT354M, gR396Q and gR398W) revealed different phenotype tendencies. Although all three mutants differentially predispose to myeloid malignancies, there was no difference in(More)
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