Prasad Patil

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BACKGROUND Large comparative genomics studies and tools are becoming increasingly more compute-expensive as the number of available genome sequences continues to rise. The capacity and cost of local computing infrastructures are likely to become prohibitive with the increase, especially as the breadth of questions continues to rise. Alternative computing(More)
In this overview to biomedical computing in the cloud, we discussed two primary ways to use the cloud (a single instance or cluster), provided a detailed example using NGS mapping, and highlighted the associated costs. While many users new to the cloud may assume that entry is as straightforward as uploading an application and selecting an instance type and(More)
A recent study of the replicability of key psychological findings is a major contribution toward understanding the human side of the scientific process. Despite the careful and nuanced analysis reported, the simple narrative disseminated by the mass, social, and scientific media was that in only 36% of the studies were the original results replicated. In(More)
  • Prasad Patil, Pierre-Olivier Bachant-Winner, Benjamin Haibe-Kains, Jeffrey T Leek
  • 2014
Background: Prior to applying genomic predictors to clinical samples, the genomic data must be properly normalized. The most effective normalization methods depend on the data from multiple patients. From a biomedical perspective this implies that predictions for a single patient may change depending on which other patient samples they are normalized with.(More)
MOTIVATION Prior to applying genomic predictors to clinical samples, the genomic data must be properly normalized to ensure that the test set data are comparable to the data upon which the predictor was trained. The most effective normalization methods depend on data from multiple patients. From a biomedical perspective, this implies that predictions for a(More)
Everyone agrees that reproducibility and replicability are fundamental characteristics of scientific studies. These topics are attracting increasing attention, scrutiny, and debate both in the popular press and the scientific literature. But there are no formal statistical definitions for these concepts, which leads to confusion since the same words are(More)
The use of genomic data in the clinic has not been as widespread as was envisioned when sequencing and genomic analysis became common techniques. An underlying difficulty is the direct assessment of how much additional information genomic data are providing beyond standard clinical measurements. This is hard to quantify in the clinical setting where(More)
In recent years, a lot of research is focused on wireless adhoc network, which is focused on field of performance, security, and energy. This paper addressed the difficulties and challenges facing the adhoc networks in security. Transmission of extremely sensitive information via one single path is not advisable as the information can easily be lost or(More)
Mobile device users use their devices any time anywhere. Hence there are different constraints we discussed on routing in MANET. Several routing protocols have been proposed in recent years for deployment of MANET. There are three types of MANET routing protocols reactive, proactive and hybrid. In this paper we have analyzed all these approaches and(More)