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Topical steroids play an extremely important role in the treatment of various dermatologic conditions. Use of topical steroids must be approached with caution, however, as they can have serious side effects. We report a case of iatrogenic perianal ulcers caused by twice-daily application of Lotrisone (clotrimazole and betamethasone dipropionate) in the… (More)
Progressive macular hypomelanosis of the trunk is a disease of unclear etiology that often goes unrecognized in the clinical setting. We present a Caucasian adolescent girl with hypopigmented macules coalescing into patches on her trunk, initially diagnosed as tinea versicolor. Upon further evaluation, the patient was found to have progressive macular… (More)
Psoriasis is a chronic inflammatory skin disease. Associated comorbidities or risks may include psoriatic arthritis, obesity, depression, smoking, diabetes, hyperlipidemia, an increased risk of cardiovascular disease with myocardial infarction, or an increased risk of lymphoma. The clinical presentation of psoriasis can range from the more common red… (More)
Pincer nail deformity has been described in association with several diseases and medications, but the mechanism of its development remains unknown. We report a woman with a rapid and severe decline in renal function that coincided with the development of pincer nails.
BACKGROUND Infliximab, a tumor necrosis factor alpha antagonist, has recently been shown to be successful for the short-term treatment of generalized pustular psoriasis (GPP) in multiple case reports. OBJECTIVE The goal of this case series was to assess the efficacy of the longer-term management of GPP with infliximab. METHODS Three patients with severe… (More)
An African American female with type II diabetes of 4 years duration presents with a 3-year history of smooth firm, dark brown plaques focally studded with comedone-like papules. Clinically and histologically her lesions were consistent with the rare entity perforating necrobiosis lipoidica.
A 42-year-old woman presented with a recurrent eruption over the distal extremities. Lesions formed a few days after initiation of intravenous immunoglobulin (IVIg) therapy and lasted 2 to 3 weeks after therapy completion. Results of a histologic examination revealed parakeratosis, exocytosis, and spongiosis. The clinical and histologic findings are similar… (More)
We report a case of subcorneal pustular dermatosis (SPD) in a patient with rheumatoid arthritis (RA) and diffuse scleroderma. Although SPD has been described in association with RA, it has not been reported in association with diffuse scleroderma to our knowledge. This observation supports the hypothesis linking immune dysfunction as a common pathogenesis… (More)
OBJECTIVE To evaluate the risk of hemolysis in subjects with glucose-6-phosphate dehydrogenase (G6PD) deficiency who were treated for acne vulgaris with either dapsone gel, 5% (dapsone gel), or vehicle gel. DESIGN Double-blind, randomized, vehicle-controlled, crossover study. SETTING Referral centers and private practice. PARTICIPANTS Sixty-four… (More)