Pranas Grybauskas

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Tissue factor is a key enzyme in coagulation process. It is primary known as a cofactor for factor VIIa-mediated triggering of blood coagulation, which proceeds in a cascade of extracellular reactions. Tissue factor forms a catalytic complex with VIIa and intitiates coagulation by activating factor IX and X, ultimately resulting in thrombin formation. Being(More)
Alpha-tocopherol content and production of malondialdehyde (MDA) was measured in liver, kidney, heart, lung, brain and skeletal muscle homogenates of control and hypoxic rats (following a 2-h-exposure to 200 mm Hg): the samples were incubated at 37 degrees C in air for 1 h. MDA production showed no relation with the content of alpha-tocopherol in control(More)
The dosage of warfarin is restricted due to its narrow therapeutic index, so, the required dose must be adapted individually to each patient. Variations in warfarin dosage are influenced by genetic factors, the changes in patient diet, anthropometric and clinical parameters. To determine whether VKORC1 G3730A and CYP4F2 G1347A genotypes contribute to(More)
BACKGROUND AND AIM OF THE STUDY Recent studies have shown that, after heart valve surgery, patients may require a more precise warfarin dosage than their non-surgical counterparts. The study aim was to analyze the influence of certain clinical factors and CYP2C9 and VKORC1 gene polymorphisms on the efficacy of initiation of warfarin treatment in patients(More)
The aim of the study was to assess the effect of aspirin or heparin pretreatment on platelet function and bleeding in the early postoperative period after coronary artery bypass grafting (CABG) surgery. Seventy-five male patients with coronary artery disease who underwent CABG with cardiopulmonary bypass (CPB) were studied. The patients were divided into(More)
The digital ultrasonic fixed path interferometer designed for testing small amounts of sample was used for the investigation of whole blood coagulation, retraction and clot melting processes. The ultrasound velocity and absorption are determined from the characteristics of an acoustic resonator consisting of an emitter, a column of liquid to be tested and a(More)
BACKGROUND Left ventricular remodeling is a complex pathologic process of progressive left ventricular dilatation, leading to dysfunction and heart failure in patients after myocardial infarction. OBJECTIVE To evaluate biochemical markers, reflecting cardiac remodeling process after first myocardial infarction and compare those markers with clinical(More)
OBJECTIVE The aim of the study was to evaluate influence of preoperative treatment with aspirin or heparin on platelet function and intensity of postoperative blood loss in early period after coronary artery bypass grafting (CABG). MATERIAL AND METHODS Study involved 75 patients (men) with ischemic heart disease, who underwent CABG. Patients were divided(More)
Various strategies have been proposed to decrease allogeneic blood transfusion requirements after cardiac surgery. The aim of the study was to evaluate the efficacy of collected and re-infused autologous shed mediastinal blood on a patient's postoperative course. Ninety patients who underwent heart surgery with cardiopulmonary bypass (CPB) were studied. The(More)
Dual antiplatelet therapy with aspirin and clopidogrel is used to lower the risk of arterial thrombosis. However, this strategy is not always successful owing to high interindividual variability in response to antiplatelet therapy. To evaluate an impact of CYP2C19 G681A and CYP4F2 G1347A polymorphisms and clinical factors on dual antiplatelet effect of(More)