Pramodkumar P. Gupta

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Melatonin is a circulating hormone that is primarily released from the pineal gland and performs a circadian rhythm in human and plays a vital role in insomnia and diabetes. In order to search promising MTNR1B homolog inhibitors, an in-silico study is carried out. Since there is no reported MTNR1B crystal structural data, three dimensional structure of(More)
In the present investigation, few 3-(substitutedphenyl)-1-[2-(1-hydroxy-ethyl)]-1H-benzimidazol-1-yl)prop-2-en-1-ones are EGFR antagonist are designed, by molecular docking analysis. The synthesized compounds were tested for their in vitro anticancer activity by propidium iodide fluorescent assay and Trypan blue viability assay against colorectal cancer(More)
Potential drug target identification and mechanism of action is an important step in drug discovery process, which can be achieved by biochemical methods, genetic interactions or computational conjectures. Sometimes more than one approach is implemented to mine out the potential drug target and characterize the on-target or off-target effects. A novel(More)
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