Pramod Yeole

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ETHNOPHARMACOLOGICAL RELEVANCE Barleria prionitis Linn. (Family: Acanthaceae), one of the important Ayurvedic medicinal plant in India, has long been used to treat variety of ailments including swellings, gout, arthritic and rheumatic disorders, nervine and skin diseases, and also acts as immunorestorative. AIM OF THE STUDY The present study was aimed to(More)
ETHNOPHARMACOLOGICAL RELEVANCE Lagenaria siceraria Stand. (Cucurbitaceae) fruits have been used, traditionally, in the treatment of hyperlipidemia and atherosclerotic impasse and considered as cardioprotective and cardiotonic drug. AIM OF THE STUDY The present work was undertaken to investigate the effects of methanolic extract from Lagenaria siceraria in(More)
Mucoadhesive temperature-mediated in situ gel formulations using chitosan and hydroxyl propyl methyl cellulose were used to enhance intranasal (i.n.) delivery of the dopamine D2 agonist ropinirole to the brain. Formulations were tested for gelation time, thermosensitivity, mucoadhesion, in vitro release and permeation, in vitro cytotoxicity, nasal(More)
The present study was undertaken to explore the immunomodulatory activity of ethanolic and water extracts of Capparis zeylanica Linn. (family: Capparidaceae) leaves on neutrophil adhesion test, humoral response to sheep red blood cells, delayed-type hypersensitivity, phagocytic activity and cyclophosphamide-induced myelosuppression. Pre-treatment of water(More)
The physiological constraints imposed by the protective mechanisms of the eye lead to low absorption of drugs and a short duration of the therapeutic effect on ocular drug delivery. Upon instillation of the eye drops only 1–10% of the drug is bioavailable while the rest is drained out of the eye through lacrimal secretions [1]. To overcome this problem(More)
Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances and hence represents a priceless tank of new bioactive molecules. Pongamia pinnata (Linn.) Pierre is one amongst these, found all over the world. It is commonly known as ‘Karanj’, and has been recognized in different traditional system of(More)
Schiff base, azetidinone and 4-thiazolidinone derivatives of para aminosalicylic acid were synthesised. It was planned to employ the structure based computer aided drug designing (CADD) to Schiff base, azetidinone and 4thiazolidinoneof para aminosalicylic acid. Approach was employed to understand the probable binding of para aminosalicylic acid on the(More)
INTRODUCTION Dissolution testing is an in vitro technique of great importance in formulation and development of pharmaceutical dosage forms,as it can be used as a substitute for in vivo studies under strictly defined and specified conditions (1). For the comparison of in vitro dissolution data and for use of such data for in vivo bioequivalence testing and(More)
The purpose of this research was to mask the intensely bitter taste of ondansetron HCl and to formulate a rapiddisintegrating tablet (RDT) of the taste-maske drug. Taste masking was done by complexing ondansetron HCl with aminoalkyl methacrylate copolymer (Eudragit EPO) in different ratios by the precipitation method. Drug-polymer complexes (DPCs) were(More)
This investigation examined the effect of a ranitidine hydrocholoride (RHCl)-ion exchange resin complexation on the drug's moisture uptake behavior. Drug resin complexes (DRCs) were prepared using the batch method with (i) two weak cation exchange resins, Polacrilex with exchangeable H+ and Polacrillin potassium; and (ii) a strong cation exchange(More)