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An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity
FtsZ is an essential bacterial guanosine triphosphatase and homolog of mammalian β-tubulin that polymerizes and assembles into a ring to initiate cell division. We have created a class of smallExpand
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Creating an Antibacterial with in Vivo Efficacy: Synthesis and Characterization of Potent Inhibitors of the Bacterial Cell Division Protein FtsZ with Improved Pharmaceutical Properties
3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties.Expand
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Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ.
The design, synthesis and structure-activity relationships of a series of oxazole-benzamide inhibitors of the essential bacterial cell division protein FtsZ are described. Compounds had potentExpand
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Design and Synthesis of some Novel oxazole derivatives and their biomedicinal efficacy
Some new 5-substituted aryl (or heteroaryl)-2-methyl-4-phenyloxazole derivatives have been synthesized by the suzuki reaction of 5-bromo-2-methyl-4-phenyloxazole [obtained by the bromination ofExpand
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Microorganisms An Alternative Menaquinone Biosynthetic Pathway Operating in
clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained byExpand