Pramit S. Malhotra

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Altered immune, inflammatory, and angiogenesis responses are observed in patients with head and neck squamous cell carcinoma (HNSCC), and many of these responses have been linked with aggressive malignant behavior and a decrease in prognosis. In this study, we examined the hypothesis that HNSCC cells produce cytokines that regulate immune, inflammatory, and(More)
Head and neck squamous cell carcinomas (HNSCC) exhibit constitutive activation of transcription factors nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1), which are modulated by the proteasome and promote resistance to cell death. HNSCC show variable sensitivity to the proteasome inhibitor bortezomib in vitro as well as in murine xenografts(More)
The Submillimeter Polarimeter for Antarctic Remote Observations (SPARO) employs two nineelement arrays of He-cooled bolometers to measure linear polarization at mm. It is operated at the focal l p 450 plane of the Viper telescope, located at the Amundsen-Scott South Pole Station. SPARO obtains better sensitivity to degree-scale polarized submillimeter(More)
OBJECTIVES To determine the incidence of posttreatment hypothyroidism in patients treated with surgery with or without radiotherapy for advanced-stage nonthyroid head and neck cancer and to make recommendations for its detection. DESIGN A prospective study to assess the incidence and time frame of occurrence of hypothyroidism in patients by primary tumor(More)
OBJECTIVES To quantify gene expression in tumor cells from human head and neck squamous cell carcinomas (HNSCC) using laser capture microdissection (LCM). STUDY DESIGN Histopathologically identified HNSCC cells were microdissected from frozen sections, RNA was isolated, and vascular endothelial growth factor (VEGF) gene expression was measured by(More)
OBJECTIVE To determine if simultaneous, bilateral lateral rhinotomies for medial maxillectomies would result in central skin or bone loss in pediatric patients with invasive fungal disease. STUDY DESIGN Retrospective chart review. SETTING Tertiary care children's hospital. PATIENTS Three children underwent surgery between April 1996 and June 1998.(More)
Head and neck squamous cell carcinomas (HNSCC) exhibit constitutive activation of transcription factors nuclear factor-KB (NF-KB) and activator protein-1 (AP-1), which are modulated by the proteasome and promote resistance to cell death. HNSCC show variable sensitivity to the proteasome inhibitor bortezomib in vitro as well as in murine xenografts and(More)
Colorimetric estimations have an important role in quantitative studies. An inexpensive and portable microprocessor-based colorimeter developed by the authors is described in this paper. The colorimeter uses a light emitting diode as the light source; a pinphotodiode as the detector and an 8085A microprocessor. Blood urea, glucose, total protein, albumin(More)
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