Prakash Namdeo Kendre

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The aim of the study was to develop and physicochemicaly characterize single unit controlled delivery system of Theophylline and was formulated as floating matrix tablet by direct compression method using gas generating agent (sodium bicarbonate) and various viscosity grades of hydrophilic polymers (HPMC K15M, K4M; HPC and Carbapol 934P). Formulation was(More)
Metaxalone is BCS class II drug having low solubility and high permeability. The solubility and bioavailability of poorly soluble drug was increased by designing microemulsion based drug delivery system of Metaxalone for oral drug administration. The microemulsion was prepared using Tween 80, PEG-400 as surfactant and cosurfactant, sesame and castor oil and(More)
Bosentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). But the solubility and bioavailability of this drug are poor, which has restricted the design and development of dosage forms for efficient and successful therapy. The present study was carried out to develop nanocomposites using an amphiphilic(More)
The present study involved the design and development of oral bioadhesive pellets of eplerenone. A solid dispersion of eplerenone was developed with a hydrophilic carrier, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus®). Bioadhesive pellets were prepared from this solid dispersion using a combination of HPMC K4M and(More)
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