Prakash Makam

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OBJECTIVES The purpose of this study was to evaluate the safety and efficacy of excimer laser atherectomy (ELA) with adjunctive percutaneous transluminal angioplasty (PTA) versus PTA alone for treating patients with chronic peripheral artery disease with femoropopliteal bare nitinol in-stent restenosis (ISR). BACKGROUND Femoropopliteal stenting has shown(More)
OBJECTIVES The ORBIT II (Evaluate the Safety and Efficacy of OAS in Treating Severely Calcified Coronary Lesions) trial evaluated the safety and efficacy of the coronary Orbital Atherectomy System (OAS) to prepare de novo, severely calcified coronary lesions for stent placement. BACKGROUND Despite advances in interventional techniques, treatment of(More)
While variations in neonatal distress vocalizations have long been shown to reflect the integrity of nervous system development following a wide range of prenatal and perinatal insults, a paucity of research has explored the neurobiological basis of these variations. To address this, virgin Sprague-Dawley rats were bred and divided into three groups: [1](More)
BACKGROUND Resistant fibrotic calcified plaque is a major limitation in treating peripheral arterial disease (PAD). Percutaneous transluminal angioplasty (PTA) balloon pressures of 8-16 atm are typically required in these lesions. Ultrasound has detected significant dissection or plaque fracture immediately after balloon dilation in 76% of patients.(More)
OBJECTIVE To report a single-center retrospective evaluation of embolic reduction strategies concurrent to infrainguinal atherectomy intervention. METHODS Fifty-five consecutive atherectomy patients from 2011 to 2012 treated with embolic reduction devices were analyzed. Embolic load was stratified by lesion type, atherectomy technique, debris capture(More)
BACKGROUND Key processes of restenosis occur weeks or months following stent implantation. Sustained drug release over time may be crucial to achieve long term vessel patency. This study compared the efficacy of a novel fluoropolymer-coated nitinol self-expanding paclitaxel-eluting stent (PES) with a clinically used PES and a bare metal stent (BMS) in a(More)
The clinical impact of embolic debris released during lower-limb interventions is a source of discussion and controversy. Yet, the sheer magnitude of their number, overall area, and morphology suggest significance, especially in complex and high-risk patients. Technologies designed for lowering embolic burden are required to improve peripheral vascular(More)
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