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Methods Fifteen year old sibling 1 presented with history of low grade fevers since 2 months, oral ulcers, malar rash, alopecia, pallor, arthralgia, history of loss of weight and appetite. Investigations revealed anaemia, leukopenia, high ESR, and low C3, C4 levels. She also had ANA +ve 1: 1280, ds DNA +ve, lupus anticoagulant +ve, anticardiolipin antibody… (More)