Prafull V Ranadive

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135  Abstract —A Streptomyces sp. MTCC 5219 isolated from a soil sample of a cow barnyard in India was found to produce a new lipase inhibitor. This bioactive compound was produced under optimum fermentation conditions and extracted by solvent extraction followed by chromatographic separation. The pure compound was found to have a molecular weight of 176(More)
Cancer stem cells (CSCs) appear to explain many aspects of the neoplastic evolution of tumors and likely account for enhanced therapeutic resistance following treatment. Dysregulated Notch signaling, which affects CSCs plays an important role in pancreatic cancer progression. We have determined the ability of Quinomycin to inhibit CSCs and the Notch(More)
Coenzyme Q10 (CoQ10) is an industrially important molecule having nutraceutical and cosmeceutical applications. CoQ10 is mainly produced by microbial fermentation and the process demands the use of strains with high productivity and yields of CoQ10. During strain improvement program consisting of sequential induced mutagenesis, rational selection and(More)
Drug resistance has become a global threat that, if not addressed, may return us to the preantibiotic era. A way to overcome the problem of growing incidence of global antibiotic resistance is to introduce compounds belonging to classes that are new to the clinic. During a screening of the marine microbial extract library for new antibiotics, one of the(More)
Type-2 diabetes is mediated by defects in either insulin secretion or insulin action. In an effort to identify extracts that may stimulate glucose uptake, similar to insulin, a high throughput-screening assay for measuring glucose uptake in skeletal muscle cells was established. During the screening studies to discover novel antidiabetic compounds from(More)
Actinomycetes are known to produce an extensive range of bioactive compounds as well as variety of enzymes having multiple biotechnological applications. They are an important source of lignocellulose hydrolyzing enzymes and constitute considerable proportion of the soil or aquatic micro-flora responsible for degradation of biomass in natural environment.(More)
The reduction of (RS)-2-(4-methoxyphenyl)-l, 5-benzothiazepin-3,4(2H,5H)-dione[(RS)-1] to (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-l,5-benzothiaepin-4(5H)-one using bakers’ yeast was carried out in the laboratory scale 10L fermenter. Under optimum reaction conditions, 200g of substrate was reduced to desired chiral intermediate in 4L reaction(More)
A screening program aimed at discovering novel anticancer agents based on natural products led to the selection of koningic acid (KA), known as a potent inhibitor of glycolysis. A method was set up to produce this fungal sesquiterpene lactone in large quantities by fermentation, thus allowing (i) an extensive analysis of its anticancer potential in vitro(More)