Pradeepa Gokina

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Although both extrinsic and intrinsic factors have been identified that orchestrate the differentiation and maturation of oligodendrocytes, less is known about the intracellular signaling pathways that control the overall commitment to differentiate. Here, we provide evidence that activation of the mammalian target of rapamycin (mTOR) is essential for(More)
Expression of E-cadherin in the peripheral nervous system is a highly regulated process that appears postnatally in concert with the development of myelinating Schwann cell lineage. As a major component of autotypic junctions, E-cadherin plays an important role in maintaining the structural integrity of noncompact myelin regions. In vivo, the appearance of(More)
The p75 neurotrophin receptor has been implicated in the regulation of multiple cellular functions that differ depending on the cell context. We have observed that p75(NTR) is strongly induced on astrocytes as well as neurons in the hippocampal CA3 region after seizures; however, the function of this receptor on these glial cells has not been defined. We(More)
Interleukin-17 (IL-17) is a cytokine that may cross the blood-brain barrier to promote inflammation and participate in the formation of lesions in patients with multiple sclerosis, where recurrent inflammatory attacks lead to oligodendrocyte loss, loss of axons, and ensuing neurological infirmities. Studies have indicated that the levels of IL-17 mRNA are(More)
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