Pradeep Varma

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Magnetic resonance imaging (MRI) is showing increased utility in examining medial temporal lobe atrophy and its relationship to memory performance in Alzheimer's disease (AD). We studied 56 AD patients and 42 older healthy subjects with neuropsychological assessment and MRI. Hippocampal and amygdaloid volumes (normalized to intracranial volume) were(More)
The X10 programming language is organized around the notion of places (an encapsulation of data and activities operating on the data), partitioned global address space (PGAS), and asynchronous computation and communication. This paper introduces an expressive subset of X10, Flat X10, designed to permit efficient execution across multiple single-threaded(More)
"Maintenance is really the normal state of an XP project" - Beck. Thus porting is a natural candidate for eXtreme Programming and we present a novel tool-based XP methodology for porting C/C++ programs. The structure provided by our tooling is designed for scalability, to enable XP on large projects porting enterprise-scale codebases. Overall planning and(More)
Yuetiva Deming1,*, Jian Xia1,2,*, Yefei Cai1, Jenny Lord1,3, Jorge L. Del-Aguila1, Maria Victoria Fernandez1, David Carrell1, Kathleen Black1, John Budde1, ShengMei Ma1, Benjamin Saef1, Bill Howells1, Sarah Bertelsen1, Matthew Bailey4, Perry G. Ridge4, Alzheimer’s Disease Neuroimaging Initiative (ADNI)¶, David Holtzman5,6,7,8, John C. Morris5,6,7,8, Kelly(More)
Despite significant progress, a disease-modifying therapy for Alzheimer’s disease (AD) has not yet been developed. Recent findings implicate soluble oligomeric amyloid beta as the most relevant protein conformation in AD pathogenesis. We recently described a signaling cascade whereby oligomeric amyloid beta binds to cellular prion protein on the neuronal(More)
Although the ApoE epsilon4 allele is well-established as the most important genetic risk factor for Alzheimer's disease (AD), the effects of this allele on regional brain atrophy in AD patients remain controversial. We performed MRI-based volumetric measurements of the hippocampus and amygdala (normalized to intracranial volume) in 32 epsilon4+ AD patients,(More)
The Clusterin (CLU) gene, also known as apolipoprotein J (ApoJ), is currently the third most associated late-onset Alzheimer's disease (LOAD) risk gene. However, little was known about the possible effect of CLU genetic variants on AD pathology in brain. Here, we evaluated the interaction between 7 CLU SNPs (covering 95% of genetic variations) and the role(More)
We describe a decision support system called Mounties that is designed for managing applications and resources using rule-based constraints in scalable mission-critical clustering environments. Mounties consists of four active service components: (1) a repository of resource proxy objects for modeling and manipulating the cluster con guration; (2) an event(More)
directed) edges in our representation enumerate only intra-variable value changes. Thus they are straightforward to represent in terms of the vertex abstraction mentioned above. An edge can optionally specify a synchrony constraint with it identifying a set of other edges that it is synchronous with. The constraint is a requirement that