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Lovastatin protects human neurons against Aβ-induced toxicity and causes activation of β-catenin–TCF/LEF signaling
Abstract Alzheimer's disease (AD) is characterized by cognitive decline due to excess amyloid beta peptide (Aβ), neurofibrillary tangles, and neuronal loss. Aβ promotes neuronal apoptosis in AD byExpand
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Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling.
Alzheimer's disease (AD) is characterized by cognitive decline due to excess amyloid beta peptide (Abeta), neurofibrillary tangles, and neuronal loss. Abeta promotes neuronal apoptosis in AD byExpand
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TGF-β1 is increased in a transgenic mouse model of familial Alzheimer's disease and causes neuronal apoptosis
Alzheimer's disease (AD) is a neurodegenerative disorder, due to excess amyloid-beta peptide (Abeta). TGF-beta1 and beta-catenin signaling pathways have been separately implicated in modulatingExpand
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Neuroprotective Role of Statins in Alzheimer`s Disease: Anti-Apoptotic Signaling~!2009-02-06~!2010-04-04~!2010-06-22~!
Alzheimer's disease (AD), a severe form of senile dementia is a neurodegenerative disorder. One of the most well characterized hallmarks of AD are extra-neuronal aggregates of amyloid-beta peptideExpand
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pathology. Analysis of proteasome function in post-mortem human AD brains has shown a strong inhibition of activity in the proteasome and lower protein levels for the Ubiquitin-C-terminal hydrolaseL1
brains has shown a strong inhibition of activity in the proteasome and lower protein levels for the Ubiquitin-C-terminal hydrolaseL1 (Uch-L1), a neuron specific enzyme, suggesting neuronalExpand