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Ca(V)1.2, the cardiac L-type calcium channel, is important for excitation and contraction of the heart. Its role in other tissues is unclear. Here we present Timothy syndrome, a novel disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent(More)
This paper presents a new indiscernibility-based rough agglomerative hierarchical clustering algorithm for sequential data. In this approach, the indiscernibility relation has been extended to a tolerance relation with the transitivity property being relaxed. Initial clusters are formed using a similarity upper approximation. Subsequent clusters are formed(More)
In the present paper, an axisymmetric two-dimensional model for powder mixed electric discharge machining (PMEDM) has been developed using the finite element method (FEM). The model utilizes the several important aspects such as temperature-sensitive material properties, shape and size of heat source (Gaussian heat distribution), percentage distribution of(More)
Immune interferon gamma (IFN-γ) is essential for mammalian host defense against intracellular pathogens. IFN-γ induces nearly 2000 host genes, yet few have any assigned function. Here, we examined a complete mouse 65-kilodalton (kD) guanylate-binding protein (Gbp) gene family as part of a 43-member IFN-γ-inducible guanosine triphosphatase (GTPase)(More)
The ability to store fat in the form of cytoplasmic triglyceride droplets is conserved from Saccharomyces cerevisiae to humans. Although much is known regarding the composition and catabolism of lipid droplets, the molecular components necessary for the biogenesis of lipid droplets have remained obscure. Here we report the characterization of a conserved(More)
Using Monte Carlo simulations and mean field calculations for a cell model of water we find a dynamic crossover in the orientational correlation time tau from non-Arrhenius behavior at high temperatures to Arrhenius behavior at low temperatures. This dynamic crossover is independent of whether water at very low temperature is characterized by a(More)
The aggregation of the amyloid-β-peptide (AβP) into well-ordered fibrils has been considered as the key pathological marker of Alzheimer's disease. Molecular attributes related to the specific binding interactions, covalently and non-covalently, of a library of compounds targeting of conformational scaffolds were computed employing static lattice atomistic(More)
Integration of climate change aspects in biodiversity management is one the fundamental requirements for long term biodiversity conservation. The explicit modelling of the biodiversity in response to climate change is the primary requirement for making any adaptation strategy. With Himalayan ecosystem in mind and Rhododendron as the species of concern, the(More)