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The tomato genome sequence provides insights into fleshy fruit evolution
TLDR
A high-quality genome sequence of domesticated tomato is presented, a draft sequence of its closest wild relative, Solanum pimpinellifolium, is compared, and the two tomato genomes are compared to each other and to the potato genome.
View on Nature
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages.
View on PubMed
Bacterial biofilms: an emerging link to disease pathogenesis.
TLDR
This chapter discusses three infections that are caused by biofilms--infectious kidney stones, bacterial endocarditis, and cystic fibrosis lung infections--and focuses on the role of the biofilm in disease pathogenesis.
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Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
TLDR
The hypothesis that P. aeruginosa might exist as biofilms—structured communities of bacteria encased in a self-produced polymeric matrix—in the cystic fibrosis lung is supported by microscopy of cystic Fibrosis sputum, which shows that the bacterium are in biofilm-like structures.
View on Nature
A component of innate immunity prevents bacterial biofilm development
TLDR
It is shown that lactoferrin, a ubiquitous and abundant constituent of human external secretions, blocks biofilm development by the opportunistic pathogen Pseudomonas aeruginosa at concentrations below those that kill or prevent growth.
View on Springer
The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity.
TLDR
Ga is investigated as a "Trojan horse" strategy that uses the transition metal gallium to disrupt bacterial Fe metabolism and exploit the Fe stress of in vivo environments and is found that Ga inhibits Pseudomonas aeruginosa growth andBiofilm formation and kills planktonic and biofilm bacteria in vitro.
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Self-generated diversity produces "insurance effects" in biofilm communities.
TLDR
It is shown that the opportunistic pathogen Pseudomonas aeruginosa undergoes extensive genetic diversification during short-term growth in biofilm communities, suggesting that self-generated diversity in biofilms provides a form of biological insurance that can safeguard the community in the face of adverse conditions.
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Cystic Fibrosis Sputum Supports Growth and Cues Key Aspects of Pseudomonas aeruginosa Physiology
TLDR
It is indicated that CF sputum readily supports high-density P. aeruginosa growth and multiple signals, which reduce swimming motility and prematurely activate the Pseudomonas quinolone signal cell-to-cell signaling cascade in P. Aerug inosa, are present in CF spUTum.
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Multidrug-Resistant Candida auris Misidentified as Candida haemulonii: Characterization by Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry and DNA Sequencing and Its…
TLDR
A cautionary approach is recommended for laboratories relying on commercial systems for identification and antifungal susceptibility testing of rare yeasts, as 90% of the isolates characterized by commercial identification systems are misidentified as C. auris.
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ExsD is a negative regulator of the Pseudomonas aeruginosa type III secretion regulon
TLDR
It is proposed that ExsD functions as an ExsA antiactivator to regulate transcription of the type III regulon and concluded that exsD is a negative regulator.
View on Wiley
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