Pradeep K. Naik

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Pseudomonas syringae is a plant pathogen which infects a wide range of plant species, and is also the causative organism of bacterial brown spot of bean. The complete genome sequence of pathogen has provided all the determinants of host-pathogen interactions and possible drug targets, computational methods for selecting suitable candidates for further(More)
The extraction of some effective features that can represent the identities of different classes plays a critical factor for any classification problems involving the analysis of complex data. Fuzzy systems are an alternative to traditional notions of set membership and logic that has its origins in ancient Greek philosophy, and applications at the leading(More)
Noscapine and its derivatives bind stoichiometrically to tubulin, alter its dynamic instability and thus effectively inhibit the cellular proliferation of a wide variety of cancer cells including many drug-resistant variants. The tubulin molecule is composed of α- and β-tubulin, which exist as various isotypes whose distribution and drug-binding properties(More)
Healthcare sector is generating a large amount of information corresponding to diagnosis, disease identification and treatment of an individual. Mining knowledge and providing scientific decision-making for the diagnosis & treatment of disease from the clinical dataset is therefore increasingly becoming necessary. Aim of this study was to assess the(More)
EHR (Electronic Health Record) system has led to development of specialized form of clinical databases which enable storage of information in temporal prospective. It has been a big challenge for mining this form of clinical data considering varied temporal points. This study proposes a conjoined solution to analyze the clinical parameters akin to a(More)
The drug yielding potential of turmeric (Curcuma longa L.) is largely due to the presence of phyto-constituent 'curcumin.' Curcumin has been found to possess a myriad of therapeutic activities ranging from anti-inflammatory to neuroprotective. Lack of requisite high curcumin containing genotypes and variation in the curcumin content of turmeric at different(More)
The International Journal of Pharma and Bio Sciences (IJPBS) is an international journal published quarterly. The Aim of IJPBS is to publish peer reviewed research and review articles in less time without much delay in the developing field of Pharmaceutical and Biological sciences. One week from the date of manuscript submission author gets the decision of(More)
This paper demonstrates the steps of a new integrating methodology to develop and analyze models of biological pathways in a systematic manner using well established Petri net technologies. The whole approach comprises stepwise modeling, animation, model validation as well as qualitative and quantitative analysis for behavior prediction. After a short(More)
A family of cystein-dependent aspartate-directed proteases, called caspases, is responsible for the proteolytic cleavage of cellular proteins leading to the characteristic apoptotic features, e.g. cleavage of caspase-activated DNase resulting in inter nucleosomal DNA fragmentation. Currently, two pathways for activating caspases have been studied in detail.(More)