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Long-term survival still eludes most patients with leukemia and non-Hodgkin's lymphoma. No approved therapies target the hallmark of the B cell, its mIgM, also known as the B-cell receptor (BCR). Aptamers are small oligonucleotides that can specifically bind to a wide range of target molecules and offer some advantages over antibodies as therapeutic agents.(More)
Oligonucleotide synthesis, purification and sequences Aptamer Sgc8 modified with reaction platform sequence and nonspecific control DNA was synthesized at the 1umole scale using standard solid-state phosphoramidite chemistry using an ABI3400 DNA/RNA synthesizer (Applied Biosystems, Foster City, CA). Dithiol phosphoramidite (DTPA) which was used at the 5'(More)
The demand has increased for sophisticated molecular tools with improved detection limits. Such molecules should be simple in structure, yet stable enough for clinical applications. Nucleic acid aptamers (NAAs) represent a class of molecules able to meet this demand. In particular, aptamers, a class of small nucleic acid ligands that are composed of(More)
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