Prabjot S. Bal

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The Japanese medaka (Oryzias latipes) early-life-stage bioassay (18-day test) provides a suitable laboratory model for the evaluation of toxicant impact. The naturally high variability in the time to hatch for medaka embryos is, however, a major limitation in terms of the duration of the test. In this study, the 18-day test was modified to use agitation to(More)
Fifty hypertensive Type 2 (non-insulin-dependent) diabetic patients were allocated, in a controlled trial, to a treatment diet of high fibre, low fat and low sodium composition, or to a control diet by the hospital dietitian. After 3 months treatment, the modified diet-treated group showed a highly significant reduction in mean systolic (180.5±19.0 to(More)
A 52 year old, right handed, hearing impaired woman was admitted with headache and neck stiffness. The only neuropsychological symptom was transient auditory perceptions in the left ear, which were musical, seemed familiar and were not influenced by verbal communication. CT and MRI showed a right subarachnoid haemorrhage, while brainstem auditory evoked(More)
We determined the success rate of new drug approval by the US FDA in two breast cancer indications, one of which used a biomarker. This allowed us to assess if biomarkers improved clinical trial risk in breast cancer. We performed a retrospective screening of industry-sponsored drug development programs registered on clinicaltrials.gov from 1998 to 2012 for(More)
SCIENCE sciencemag.org G lobal progress toward meeting the Convention on Biological Diversity (CBD) Aichi targets has recently been found wanting ( 1). The Aichi targets were intended to be SMART (specific, measurable, ambitious, realistic, and time-bound), partly in response to the perception that failure to meet the preceding global biodiversity targets(More)
Fifty-three diabetic patients with mild hypertension were allocated to a treatment diet with a high fibre, low fat and low sodium dietary regime or a control diet. After a 1-month treatment period, the modified-diet treated group (n = 35) showed a highly significant reduction in mean diastolic blood pressure (P less than 0.001) accompanied by significant(More)
Processing of Heart Rate Variability (HRV) signal becomes more and more important for functional assessment of patient's health. When developing Hybrid Models of cardiopulmonary system we need to make possible taking into account heart rate variability. Our aim is to generate signals that have properties similar to HRV in norm and in different pathologies.(More)
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