Prabhakar Chalise

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Nicotine improves cognitive enhancement and there are indications that neurodegenerative (age-related) cognitive disorders could be treated with nicotine-based drugs. The zebra finch is a well-recognized model to study cognitive functioning; hence this model could be used to study the effects of nicotine in neurodegenerative cognitive disorders. However,(More)
The Cox proportional hazards model is widely used for analyzing associations between risk factors and occurrences of events. One of the essential requirements of defining Cox proportional hazards model is the choice of a unique and well-defined time scale. Two time scales are generally used in epidemiological studies: time-on-study and chronological age.(More)
Canonical correlation analysis (CCA) is a widely used multivariate method for assessing the association between two sets of variables. However, when the number of variables far exceeds the number of subjects, such in the case of large-scale genomic studies, the traditional CCA method is not appropriate. In addition, when the variables are highly correlated(More)
SUMMARY The Cox proportional hazards model is routinely used to determine the time until an event of interest. Two time scales are used in practice: time-on-study and chronological age. The former is the most frequently used time scale both in clinical studies and longitudinal observation studies. However, there is no general consensus about which time(More)
Both genetic and epigenetic factors influence the development and progression of epithelial ovarian cancer (EOC). However, there is an incomplete understanding of the interrelationship between these factors and the extent to which they interact to impact disease risk. In the present study, we aimed to gain insight into this relationship by identifying DNA(More)
Recently, structural variation in the genome has been implicated in many complex diseases. Using genomewide single nucleotide polymorphism (SNP) arrays, researchers are able to investigate the impact not only of SNP variation, but also of copy-number variants (CNVs) on the phenotype. The most common analytic approach involves estimating, at the level of the(More)
Recent technological innovations have catalyzed the generation of a massive amount of data at various levels of biological regulation, including DNA, RNA and protein. Due to the complex nature of biology, the underlying model may only be discovered by integrating different types of high-throughput data to perform a " meta-dimensional " analysis. For this(More)
Copy number variants (CNVs) have been implicated in many complex diseases. We examined whether inherited CNVs were associated with overall survival among women with invasive epithelial ovarian cancer. Germline DNA from 1,056 cases (494 deceased, average of 3.7 years follow-up) was interrogated with the Illumina 610 quad genome-wide array containing, after(More)
SUMMARY The Cox proportional hazards model is widely used in time-to-event analysis. Two time scales are used in practice: time-on-study and chronological age. The former is the most frequently used time scale both in clinical studies and longitudinal observation studies. There is no general consensus about which time scale is the best. It has been asserted(More)
From March through August 2015, nearly 60 teams from around the world participated in the Prostate Cancer Dream Challenge (PCDC). Participating teams were faced with the task of developing prediction models for patient survival and treatment discontinuation using baseline clinical variables collected on metastatic castrate-resistant prostate cancer (mCRPC)(More)