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BACKGROUND Growing evidence shows that the etiological causes and pathological processes underlying major depressive disorder (MDD) and schizophrenia (SCZ) overlap. Our previous study revealed a strong association between the polymorphism ss178077483 in the miRNA-30e precursor (pre-miR-30e) and the risk of SCZ. We thus hypothesized that this SCZ risk allele(More)
MicroRNAs (miRNAs) are short, non-coding RNAs that regulate the stability and translation of mRNA targets. Increasing evidence suggests that miRNAs could be involved in the initiation and progression of neuropsychiatric disorders. Prior to this study, six miRNAs had been reported to show a significantly abnormal expression level in schizophrenic brains.(More)
Dopamine signaling is strongly implicated in the etiology of schizophrenia (SZ). Because of the essential role dopamine D2 receptor (DRD2) in dopamine signaling, DRD2 gene has been regarded as one of the top candidate genes for SZ. However, the findings from linkage and association analyses on this gene are mixed and largely inconsistent across various(More)
Non-traditional (Eastern/non-conventional) treatments have gained increased interest and recognition recently. The utilization of these treatments in psychiatry challenges mental health professionals to examine the impact of cultural factors and the bi-directional effects of body on mind and mind on body when treating psychiatric illnesses. Professionals in(More)
Recent research on suicide in China reveals several unique findings: 1) female suicides outnumber male suicides by a 3:1 ratio; 2) rural suicides outnumber urban suicides by a 3:1 ratio; 3) a large upsurge of young adult and older adult suicides has occurred; 4) a comparatively high national suicide rate two to three times the global average is evident;(More)
BACKGROUND Since the serotonin (5-HT) is associated with circadian rhythm and breathing regulation, the serotonin transporter (5-HTT), which plays an important role in serotoninergic transmission, might be a strong candidate gene in the pathogenesis of obstructive sleep apnea syndrome (OSAS). OBJECTIVE To investigate the association of 5-HTT gene(More)
Multi-channel near-infrared spectroscopy (NIRS) is a noninvasive and low-cost functional neuroimaging technique in psychiatric research, and it has been wildly used for detecting the spatiotemporal characteristics of brain activity. In order to evaluate the clinical value of NIRS data in the assistant diagnosis of major depressive disorder (MDD), prefrontal(More)
The dopamine D3 receptor has been implicated in the pathophysiology of schizophrenia (SZ). A glycine-to-serine polymorphism at codon 9 of the dopamine D3 receptor gene (DRD3), rs6280, has been widely studied for its association with SZ, but with conflicting results. Altered levels of DRD3 mRNA have also been reported in SZ compared with normal controls.(More)
"M. -s. X" was a 29-year-oid married woman living witii her teenage daughter and her parents-in-iaw in a farming viiiage of 700 in centrai China whiie her husband wori<ed in a coastai city. For many years, Ms. X had experienced her in-iaws as contemptuous and resentfui because she had not produced a son for the family. Increasingly, she had been struggling(More)
BACKGROUND Glycogen synthase kinase-3 (GSK-3) has been linked to prodepressant-like effects in rodents. However, the roles of GSK-3β and the hippocampal dentate gyrus in regulating these behavioral effects remain unclear. METHODS A lentiviral vector was utilized to site-specifically express GSK-3β constitutively in the hippocampal DG in a mouse model of(More)