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Differential effects of estrone and estrone-3-O-sulfamate derivatives on mitotic. Arrest, apoptosis, and microtubule assembly in human breast cancer cells.
- L. MacCarthy-Morrogh, P. Townsend, +4 authors G. Packham
- Biology, Medicine
- Cancer research
- 1 October 2000
There is considerable interest in the potential use of estrogen derivatives for the treatment and prevention of breast cancer. We demonstrated previously that the sulfamoylated estrone derivative… Expand
Xylopyranoside-based agonists of D-myo-inositol 1,4,5-trisphosphate receptors: synthesis and effect of stereochemistry on biological activity.
- H. Rosenberg, A. Riley, R. D. Marwood, V. Corrêa, C. Taylor, Potter BVL
- Chemistry, Medicine
- Carbohydrate research
- 8 May 2001
The synthesis of a series of tetrahydrofuranyl alpha- and beta-xylopyranoside trisphosphates, designed by excision of three motifs of adenophostin A is reported. The synthetic route features improved… Expand