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The effects of sera obtained from 18 patients with homozygous beta-thalassemia on the adherence and chemotaxis of normal polymorphonuclear leukocytes (PMNLs) was studied. The adherence of PMNLs suspended in thalassemic serum was 3.1% +/- 2.5% (mean +/- SD) compared with 17.9% +/- 8.0% adherence in control serum (P less than 0.00001). Zymosan-treated(More)
The chemotactic response of human polymorphonuclear leukocytes (PMNLs) to gentamicin-sensitive and gentamicin-resistant strains of Pseudomonas aeruginosa was studied. Filtrates from the resistant strains markedly enhanced the chemotactic response of human PMNLs (leukotactic index [LI] = 40.4 micron), in contrast to the filtrates from the sensitive strains,(More)
The ability of human polymorphonuclear leucocytes (PMNs) to ingest and kill gentamicin-sensitive and resistant Pseudomonas aeruginosa strains was studied. Strains becoming resistant to gentamicin either by laboratory training or through an R-factor were more susceptible to the phagocytic and bactericidal function of the PMNs. These results may explain(More)
Culturing Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae in the presence of subinhibitory concentrations (1/4 MIC) of trimethoprim, sulphamethoxazole or their combination, resulted in reduced adherence of all the above strains. The number of phagocytosed bacteria pre-exposed to subinhibitory concentrations of the above antibiotics was not(More)
The adherence of strains of Candida albicans to buccal epithelial cells as well as the phagocytosis of these organisms by human polymorphonuclear leucocytes (PMNL) was studied. The strains of C. albicans were obtained from patients' urine. from bird faeces and from soil. The strains of C. albicans obtained from patients and the environment displayed greater(More)
Anesthetic agents may impair host defense mechanisms including polymorphonuclear leukocyte (PMNL) function. We have studied the effects of thiopentone and propofol in low (thiopentone 10 mg/L, propofol 2 mg/l) and high (thiopentone 40 mg/L, propofol 6 mg/L) clinically relevant concentrations on PMNL adherence, chemotaxis, phagocytosis and killing in vitro.(More)
The effect of pre-incubating Staphylococcus aureus, Streptococcus pneumoniae and Streptococcus pyogenes with subinhibitory concentrations of lincomycin was studied with respect to polymorphonuclear leukocyte function against these organisms. Culturing the above organisms in the presence of lincomycin (1/4 MIC) resulted in a significant enhancement of(More)
The effect of pre-incubation of Pseudomonas aeruginosa, Klebsiella pneumoniae and Proteus mirabilis with sub-inhibitory concentrations (sub MICs) of clindamycin on the adherence of these organisms was studied. Culturing these organisms in the presence of clindamycin (4 mg/l) resulted in significant enhancement of adherence for Ps. aeruginosa and Pr.(More)
The ability of polymorphonuclear leucocytes (PMNs) from elderly healthy subjects and post-operative cancer patients to ingest and killClostridium difficile was studied. The percentage of phagocytosis in clinically healthy subjects aged 69–82 years ranged from 20.2±3.2 (mean±SD) to 34.1±4.2, depending on the strain ofC. difficile, from 6.7±2.2 to 11.2±2.2 in(More)