Pooja Wasson

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The ability to grip objects allows us to perform many activities of daily living such as eating and drinking. Lesions to and disorders of the basal ganglia can cause deficits in grip force control. Although the prediction of grip force amplitude is an important component of performing a grip force task, the extant literature suggests that this process may(More)
Previous work using visual feedback has identified two distinct sensorimotor circuits in the basal ganglia (BG): one that scaled with the duration of force and one that scaled with the rate of change of force. The present study compared functional MRI signal changes in the BG during a grip force task using either visual or auditory feedback to determine(More)
Besides its function as a major electon acceptor, NAD is a substrate for numerous ADP-ribose transfer reactions that are important in the regulation of cell function. The poly(ADP-ribosyl)ation of nuclear proteins has been shown to modify chromatin structure. The mono(ADP-ribosyl)ation of elongation factor-2, catalyzed by diphtheria and psuedomonas toxins,(More)
Unlike other nucleoside anti-metabolites, 2-chlorodeoxyadenosine is selectively toxic at nanomolar concentrations to human lymphocytes and monocytes. In susceptible cells, the drug causes a dose- and time-dependent accumulation of DNA strand breaks, with resultant activation of poly(ADP-ribose) polymerase. Furthermore, the actions of 2-chlorodeoxyadenosine(More)
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