• Publications
  • Influence
Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG-lipids.
Four structurally related, acid-labile polyethylene glycol (PEG) conjugated vinyl ether lipids have been synthesized and used at low molar ratios to stabilize the nonlamellar, highly fusogenic lipid,Expand
  • 163
  • 3
Thermally and photochemically triggered self-assembly of peptide hydrogels.
Self-assembling systems present attractive platforms for engineering stimulus-responsive materials with controlled nanoand microstructures. Recent efforts to design such systems include syntheticExpand
  • 167
  • 2
Open Access
Acid-labile mPEG-vinyl ether-1,2-dioleylglycerol lipids with tunable pH sensitivity: synthesis and structural effects on hydrolysis rates, DOPE liposome release performance, and pharmacokinetics.
A family of 3-methoxypoly(ethylene glycol)-vinyl ether-1,2-dioleylglycerol (mPEG-VE-DOG) lipopolymer conjugates, designed on the basis of DFT calculations to possess a wide range of protonExpand
  • 30
  • 1
Tumor Selective Silencing Using an RNAi-Conjugated Polymeric Nanopharmaceutical.
Small interfering RNA (siRNA) therapeutics have potential advantages over traditional small molecule drugs such as high specificity and the ability to inhibit otherwise "undruggable" targets.Expand
  • 15
  • 1
Formation of fibrinogen-based hydrogels using phototriggerable diplasmalogen liposomes.
We report the triggered release of Ca2+ from liposomal compartments to induce rapid gelation of protein-based hydrogels. Phototriggerable liposomes were designed by entrapping CaCl(2) withinExpand
  • 31
Open Access
Design, synthesis and application of vinyl ether compounds for gene and drug delivery.
  • 3
Acid- and Oxidatively-Labile Vinyl Ether Surfactants: Synthesis and Drug Delivery Applications
Liposomes have now evolved into a commercially-important drug delivery vehicle by overcoming a host of problems that were initially encountered with first generation liposomes. In spite of theseExpand
  • 8
Discovery of a Novel Cabazitaxel Nanoparticle-Drug Conjugate (CRLX522) with Improved Pharmacokinetic Properties and Anticancer Effects using a β-Cyclodextrin-PEG Copolymer-Based Delivery Platform.
Novel nanoparticle-drug conjugates (NDCs) containing diverse, clinically-relevant anticancer drug payloads (docetaxel, cabazitaxel, and gemcitabine) were successfully generated and tested in drugExpand
  • 2
Abstract B176: In vitro and in vivo studies demonstrating sustained drug release for multiple anticancer payloads and improved anticancer effects of a cabazitaxel β-cyclodextrin-PEG copolymer-based
We have demonstrated the ability to generate nanoparticle-drug conjugates (NDCs) with tunable and diverse in vitro and in vivo drug release kinetics by the conjugation of multiple anticancer agentsExpand