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Two experiments were conducted in rabbits to examine the effects of ketamine (0, 100, and 200 mg/kg) on the acquisition and retention of the classically conditioned nictitating membrane response (NMR). Classical conditioning of the NMR was accomplished by pairing tone and light conditioned stimuli (CS) with paraorbital shock as the unconditioned stimulus(More)
The purpose of this study was to determine whether acute tolerance develops to the motor control effects of the short-acting benzodiazepine, midazolam. Using a bolus and constant infusion scheme, 40 healthy adults received a 70-min intravenous infusion of either saline (n = 20) or 6.1 (SE = 0.2) mg midazolam (n = 20). Following the 70-min infusion period,(More)
BACKGROUND/AIMS The majority of hepatocellular carcinoma patients with cirrhosis are not candidates for surgical resection, and local thermal therapy producing destruction of cancer cells was one of the ideal options for treatment. Heat from radiofrequency ablation is generated through agitation caused by an alternating electrical current. The heat of(More)
Four experiments were conducted to determine the effects of sodium pentobarbital (0, 3, 9, and 15 mg/kg) on the acquisition of the rabbit's classically conditioned nictitating membrane response (NMR) and to determine the locus of the drug's effects on sensory, motor, associative, and nonassociative processes. In experiment 1, classical conditioning of the(More)
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