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Drosophila affords a genetically well-defined system to study apoptosis in vivo. It offers a powerful extension to in vitro models that have implicated a requirement for cytochrome c in caspase activation and apoptosis. We found that an overt alteration in cytochrome c anticipates programmed cell death (PCD) in Drosophila tissues, occurring at a time that(More)
RNA silencing processes are guided by small RNAs known as siRNAs and microRNAs (miRNAs) . They reside in ribonucleoprotein complexes, which guide the cleavage of complementary mRNAs or affect stability and translation of partial complementary mRNAs . Argonaute (Ago) proteins are at the heart of silencing effector complexes and bind the single-stranded siRNA(More)
MicroRNAs are small noncoding RNAs that control gene function posttranscriptionally through mRNA degradation or translational inhibition. Much has been learned about the processing and mechanism of action of microRNAs, but little is known about their biological function. Here, we demonstrate that injection of 2'O-methyl antisense oligoribonucleotides into(More)
—This paper presents a performance modeling and optimization analysis tool to predict and optimize the performance of sparse matrix-vector multiplication (SpMV) on GPUs. We make the following contributions: (1) We present an integrated analytical and profile-based performance modeling to accurately predict the kernel execution times of CSR, ELL, COO, and(More)
We examined post-eclosion elimination of the Drosophila wing epithelium in vivo where collective "suicide waves" promote sudden, coordinated death of epithelial sheets without a final engulfment step. Like apoptosis in earlier developmental stages, this unique communal form of cell death is controlled through the apoptosome proteins, Dronc and Dark,(More)
mTor kinase is involved in cell growth, proliferation, and differentiation. The roles of mTor activators, Rheb1 and Rheb2, have not been established in vivo. Here, we report that Rheb1, but not Rheb2, is critical for embryonic survival and mTORC1 signaling. Embryonic deletion of Rheb1 in neural progenitor cells abolishes mTORC1 signaling in developing brain(More)
LSQR (Sparse Equations and Least Squares) is a widely used Krylov subspace method to solve large-scale linear systems in seismic tomography. This paper presents a parallel MPI-CUDA implementation for LSQR solver. On CUDA level, our contributions include: (1) utilize CUBLAS and CUSPARSE to compute major steps in LSQR; (2) optimize memory copy between host(More)
Currently, numerically simulated synthetic seismograms are widely used by seismologists for seismological inferences. The generation of these synthetic seismograms requires large amount of computing resources, and the maintenance of these observed seismograms requires massive storage. Traditional high-performance computing platforms is inefficient to handle(More)
With its rapid development, cloud computing has been increasingly adopted by scientists for large-scale scientific computation. Compared to the traditional computing platforms such as cluster and supercomputer, cloud computing is more elastic in the support of real-time computation and more powerful in the management of large-scale datasets. This paper(More)
In flies and mammals, critical regulators of cell death function by antagonizing Inhibitor of Apoptosis Proteins (IAPs), which themselves directly block caspase action. The three currently known IAP antagonists in Drosophila map to the H99 genomic interval required for all programmed cell death. Here we describe a fourth member of this genetic group, sickle(More)