Plamen I Zagorchev

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The effect of different doses of visible (Vis), ultraviolet-capital A, Cyrillic (UVA), and mixed light (UVA + Vis) upon coenzyme Q(10) (CoQ(10)) and beta-carotene synthesis and biomass yield by the Sporobolomyces salmonicolor AL(1), Cryptococcus albidus AS(55), Cryptococcus laurentii AS(56), and C. laurentii AS(58) strains isolated from Antarctic samples(More)
The Sporobolomyces salmonicolor AL(1) Antarctic strain was cultivated and two bioproducts were obtained: exopolysaccharide and biomass. The biologically active substances ergosterol, torularhodin, torulene, β-carotene and CoQ(10) were extracted from the biomass and were quantified as follows: ergosterol 5.2 ± 0.2 mg/g, torularhodin 458.3 ± 24.5 μg/g,(More)
A series of different 1-monosubstituted and 1,1-disubstituted 1,2,3,4-tetrahydro-isoquinolines was synthesized in high yields from different ketoamides. We have developed a convenient method for the synthesis of disubstituted derivatives by interaction of ketoamides with organomagnesium compounds, followed by cyclization in the presence of catalytic amounts(More)
UNLABELLED Betahistine dihydrochloride is a histamine-like drug widely used in relieving the symptoms associated with Ménière's syndrome. Pharmacokinetic studies of betahistine have demonstrated that it has a short plasma half-life of 3-4 hours. In such cases frequent administration of the drug is required in order to keep plasma concentration within the(More)
OBJECTIVE Peat and water extracts from peat have been reported in the literature to have an effect on the spontaneous contractile activity of certain smooth muscles. The purpose of the present study was to investigate the effect of organic substances of various molecular weight contained in the water peat extracts on the spontaneous contractile activity of(More)
Between 1990 and 2001 in Thoracic Surgery Department at SHATPD "Saint Sophia"--Sofia a total of 821 patients with pulmonary hydatidosis were operated on. In 5 (0.6%) of them the cysts were situated in the both lungs, lever and spleen. For the first time in the surgical practice a sterno-laparotomy were carried out for one-stage cysts' removal in this(More)
PURPOSE The aim of this study is to evaluate the effect of retigabine on the smooth muscle response to acetylcholine, adrenaline, α-and β-adrenoceptor agonists. METHODS We studied the change in the spontaneous smooth muscle contraction of guinea pig gastric corpus strips before and after 20-min treatment with 2μM retigabine. We also evaluated the effect(More)
Ethosuximide is an alternative medicament that is used for coupling of petit mal, especially in childhood. Some clinical observations show that it has secondary effects on the gastro intestinal tract (GIT). The present research tries to define the characteristics of Ethosuximide--the inducted secondary effects on the GIT, and to explain some of the possible(More)
Objective: The objective of this study was to examine and characterize topical eye drops with indomethacin-loaded poly(vinyl acetate) nanoparticles (IMC-p(VAc)-NPs). Methods: IMC-p(VAc)-NPs were obtained by emulsifier-free radical homopolymerization of the monomers in the presence of indomethacin in water and in an aqueous solution of Carbopol®. Thus(More)
Comet assay is an invaluable tool in DNA research. It is widely used to detect DNA damage as an indicator of exposure to genotoxic stress. A canonical set of parameters and specialized software programs exist for Comet assay data quantification and analysis. None of them so far has proven its potential to employ a computer-based algorithm for assessment of(More)