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Mechanisms of resistance to azacitidine in human leukemia cell lines.
The DNA methylation inhibitor azacitidine (5-azacytidine) is used against myelodysplastic syndrome and acute myeloid leukemia, but drug resistance is an ongoing, intractable problem. To investigateExpand
Vincristine potentiates the anti-proliferative effect of an aurora kinase inhibitor, VE-465, in myeloid leukemia cells.
Aurora kinases play an essential role in the regulation of mitosis. The kinases are overexpressed in a variety of cancer cells and are involved in tumorgenesis. Although aurora kinase inhibitors areExpand
Romidepsin Overcomes Cell Adhesion-Mediated Drug Resistance in Multiple Myeloma Cells
5] . These effects might ultimately affect the expression and function of various intracellular molecules, including transcription factors. We therefore hypothesized that these agents influence theExpand
Overcoming Resistance to 5-Azacytidine in Acute Myelogenous Leukemia
Abstract 1370 Background: The DNA methylation inhibitor 5-azacytidine (AZA), which is approved for treatment of myelodysplastic syndrome, is also a potential agent for treatment of leukemia; however,Expand
Combined azacitidine and romidepsin enhances cytotoxicity in azacitidine-sensitive but not in azacitidine-resistant multiple myeloma cell lines.
In hematopoietic tumor cells, aberrant epigenetic alterations of hypermethylation or histone deacetylation are usually observed. In multiple myeloma (MM), histone deacetylase inhibitors (HDIs) haveExpand