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Triplet Chemotherapy (FOLFOXIRI) Plus Bevacizumab Versus Doublet Chemotherapy (FOLFOX/FOLFIRI) Plus Bevacizumab in Conversion Therapy for Metastatic Colorectal Cancer: a Meta-Analysis
- Lin Shui, Yushen Wu, Huapeng Lin, Pixian Shui, Qin Sun, Xiaopin Chen
- MedicineCellular Physiology and Biochemistry
- 1 August 2018
Triplet chemotherapy plus Bev significantly improved the R0 resection rates, ORR, PFS and OS in comparison with doublet chemotherapy with bevacizumab (Bev) in conversion therapy for mCRC patients, with a higher risk of neutropenia and diarrhea.
In vitro anti-viral effect of fructopyrano-(1→4)-glucopyranose from Radix isatidis on infuenza virus A
- Qin Sun, Pixian Shui, Hanqing Li, Sijin Yang, Minghua Liu, Shi-jie Zhang
- Chemistry, Biology
- 30 July 2012
Results showed the in vitro cell protection rate and virus inhibition rate increased significantly with the increase of FG concentration when compared with cells without FG treatment, indicating FG can confer obvious antiviral effects on influenza A virus in vitro.
The Era of Radiogenomics in Precision Medicine: An Emerging Approach to Support Diagnosis, Treatment Decisions, and Prognostication in Oncology
The integrated process of radiogenomics is summarized and the crucial strategies and statistical algorithms involved in current studies are introduced to facilitate computer-aided diagnosis, treatment, and prediction of the prognosis in patients with tumors in the routine clinical setting.
Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities
- Juan Lu, Qin Sun, Zheng-chao Tu, Qing Lv, Pixian Shui, Yong‐Xian Cheng
- 27 August 2015
Three new N-acetyldopamine dimers molossusamide A–C (1−3) and two known compounds 4 and 5 are identified by comprehensive spectroscopic evidences.
Fructopyrano-(1→4)-glucopyranose inhibits the proliferation of liver cancer cells and angiogenesis in a VEGF/VEGFR dependent manner.
- Minghua Liu, Sijin Yang, Qin Sun
- Biology, MedicineInternational journal of clinical and…
- 15 November 2014
FG was able to remarkably inhibit the proliferation, migration and angiogenesis of HMECs, exerting anti-angiogenetic effect in cancer-bearing nude mice and was found to inhibit the tumor growth, reduce MVD in tumors and decrease the VEGF in tumors.
Durable Response and Good Tolerance to the Triple Combination of Toripalimab, Gemcitabine, and Nab-Paclitaxel in a Patient With Metastatic Pancreatic Ductal Adenocarcinoma
As the first-line treatment of metastatic PDAC patients, GA plus toripalimab may provide a novel combined approach with favorable response and manageable toxicity.
Study protocol for an open-label, single-arm, phase Ib/II study of combination of toripalimab, nab-paclitaxel, and gemcitabine as the first-line treatment for patients with unresectable pancreatic…
This trial is the first attempt to evaluate the efficacy and safety of the combination of toripalimab plus AG chemotherapy as a first-line treatment for unresectable PDAC patients and will provide preliminary evidence for further assessment of this combined therapeutic regimen.
Long-Term Results of Partial Breast Irradiation After Breast-Conserving Surgery for Early Stage Breast Cancer: A Prospective Phase II Trial in China
This study suggested that PBI had durable local control and maintained good cosmetic outcomes with minimal late toxicity at long term follow up for the early stage breast cancer patients.
Targeted Inhibition of the Immunoproteasome Blocks Endothelial MHC Class II Antigen Presentation to CD4 + T Cells in Chronic Liver Injury
CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma
High CDC6 expression may serve as a promising biomarker for prognosis and correlated with immune infiltrates, presenting to be a potential immune therapy target in glioma.