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The behavioral and cognitive effects of nicotine suggest that nicotinic acetylcholine receptors (nAChRs) participate in central nervous system (CNS) function. Although nAChR subunit messenger RNA (mRNA) and nicotine binding sites are common in the brain, there is little evidence for synapses mediated by nAChRs in the CNS. To test whether, CNS nAChRs might(More)
We report here that neuregulin (NRG) isoforms with a conserved cysteine-rich domain (CRD) in their N terminus regulate expression of nicotinic acetylcholine receptors (nAChRs) at developing interneuronal synapses and report the isolation of transmembrane NRG isoforms with this CRD within the N-terminal portion. CRD-NRG mRNA and immunoreactive protein are(More)
Previous work has established that synaptic input influences the differentiation of muscle and glandular targets and that these targets reciprocally influence the differentiation of the innervating neurons. In contrast, there is little information on the impact of pre- vs postsynaptic contact on the differentiation of neuronal targets. We have delineated(More)
1. GABAA receptor-mediated synaptic innervation of oxytocin neurones in the supraoptic nucleus (SON) was analysed in adult female rats going through their first reproductive cycle by recording the spontaneous inhibitory postsynaptic currents (sIPSCs) at six stages of female reproduction. 2. During pregnancy we observed a reduction in the interval between(More)
Although multiple related genes encoding nicotinic acetylcholine receptor (AChR) subunits have been identified, how each of these subunits contributes to AChRs in neurons is not known. Sympathetic neurons express four classes of AChR channels and six AChR subunit genes (alpha 3, alpha 4, alpha 5, alpha 7, beta 2, and beta 4). The contribution of individual(More)
Neuronal differentiation and development of synaptic specializations are strongly influenced by cellular interactions. We compared the effects of interaction with distinct autonomic targets on the molecular and biophysical differentiation of 'upstream' neuron-neuron synapses. Contact with cardiac tissue induced expression of nicotinic receptor channels(More)
The Hawaiian sepiolid squid Euprymna scolopes uses the luminescence of bacterial symbionts in its nocturnal behavior. This ventral dissection (the squid is-3.5 centimeters in length) reveals the light-emitting organ as a complex, bibbed structure in the center of the mantle cavity. Normal light-organ development is initiated by specific strains of Vibrio(More)
articles The formation, maintenance and remodeling of synapses involves regulated expression and targeting of specific transmitter receptors to sites of cellular contact. Presynaptic input and input-derived signals are potentially important regulators of receptor expression at neuron–neuron synapses. In particular, expression of specific subtypes of(More)
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