Pirkko Pohjanpelto

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The fate of visual fields in 42 eyes with capsular glaucoma followed for 5 to 14 years (mean 9.1 years) and 46 eyes with simple glaucoma followed for 5 to 14 years (mean 10.2 years) was studied retrospectively. In the treatment the IOP levels were around 19.5 mmHg. In both groups the visual field deteriorated in 70-80% of eyes, and 11% of patients became(More)
Twenty chalazia were treated with intralesional triamcinolone acetonide injections. The diameter of 9 of the chalazia was less than 6 mm. Eight of them were cured after a single injection and 1 after 2 injections. The diameter of 11 of the chalazia was greater than or equal to 6 mm. Four cases responded to 1 injection and 5 to 2 injections. Two were(More)
Data on 144 patients who in 1969-1973 were found to have ocular hypertension greater than or equal to 25 mmHg without glaucomatous damage were collected retrospectively. Intraocular pressure-lowering treatment was prescribed with few exceptions. Thirteen out of 37 patients (35%) with exfoliation syndrome developed glaucomatous damage during the follow-up(More)
In mammalian cells DNA synthesis is more complicated than in prokaryotes and less well understood. Here we incubated intact mammalian cells (polyamine auxotrophic Chinese hamster ovary cells and primary human fibroblasts) with [32P]orthophosphate and found that, besides high molecular weight DNA, a species of low molecular weight DNA, approximately 450 bp(More)
Genotyping of hepatitis C virus (HCV) is important because of its clinical and epidemiological implications. We report here the distribution of HCV genotypes in various patient groups in Finland using a rapid and reliable HCV typing method based on restriction fragment length polymorphism (RFLP) of the amplified DNA from the 5' non-coding region of the(More)
Polyamines are found in all cells but their function is not fully understood. We have studied the effect of polyamines on the passage of cells through the cell cycle using a polyamine auxotrophic mutant, CHO-P22, which has no detectable ornithine decarboxylase activity. The ability of these cells to grow without serum allows efficient polyamine depletion. A(More)
The relationship between Na entry and the activity of the Na-K pump has been investigated in a variety of cell types by testing the effect of the Na ionophore monensin, mitogenic stimulation with serum and oncogenic transformation by SV40 and polyoma virus. We found that addition of monensin increases intracellular Na in quiescent cultures of murine,(More)
OBJECTIVES Because of the suboptimal efficacy, cost, and adverse effects of interferon in chronic hepatitis C (HCV), predictors have been sought to detect patients with a good treatment response. Also, markers for determining a poor response early in the course of therapy, such as the lack of early viral clearance, have been proposed. METHODS Ninety-seven(More)