• Publications
  • Influence
Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets
BackgroundGenome-wide association studies (GWAS) have recently identified many new genetic variants associated with the development of type 2 diabetes. Many of these variants are in introns of knownExpand
  • 27
  • 2
Glycoprotein 130 Receptor Signaling Mediates α-Cell Dysfunction in a Rodent Model of Type 2 Diabetes
Dysregulated glucagon secretion accompanies islet inflammation in type 2 diabetes. We recently discovered that interleukin (IL)-6 stimulates glucagon secretion from human and rodent islets. IL-6Expand
  • 19
  • 2
  • PDF
Nutritional regulation of genome-wide association obesity genes in a tissue-dependent manner
BackgroundGenome-wide association studies (GWAS) have recently identified several new genetic variants associated with obesity. The majority of the variants are within introns or between genes,Expand
  • 37
  • 1
  • PDF
Abstract 4986: Distinct temporal regulation of RET isoform internalization: Roles of clathrin and AP2
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA The RET receptor tyrosine kinase is an important contributor to kidney and enteric nervous system development. InExpand
  • 1
  • 1
Distinct Temporal Regulation of RET Isoform Internalization: Roles of Clathrin and AP2
The RET receptor tyrosine kinase (RTK) contributes to kidney and nervous system development, and is implicated in a number of human cancers. RET is expressed as two protein isoforms, RET9 and RET51,Expand
  • 21
Abstract 4994: RET isoforms differentially contribute to focal adhesion formation
RET is a receptor tyrosine kinase crucial for the development of the kidney, and some neuroendocrine tissues. RET activation by its ligand, glial cell-line derived neurotrophic factor (GDNF), resultsExpand