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Diabetes genes identified by genome-wide association studies are regulated in mice by nutritional factors in metabolically relevant tissues and by glucose concentrations in islets
TLDR
Insight is provided into the metabolic regulation of these new type 2 diabetes genes discovered by the first waves of GWAS that will be important for determining how the GWAS variants affect gene expression and ultimately the development of type 1 diabetes. Expand
Glycoprotein 130 Receptor Signaling Mediates α-Cell Dysfunction in a Rodent Model of Type 2 Diabetes
TLDR
It is concluded that in a setting of islet inflammation and pathophysiology modeling type 2 diabetes, activation of α-cell gp130 receptor signaling has deleterious effects on α- cell function, promoting hyperglycemia. Expand
Nutritional regulation of genome-wide association obesity genes in a tissue-dependent manner
TLDR
These data show nutritional regulation of nearly all these GWAS obesity genes, particularly in the brain and adipose tissue, and provide support for their role in the development of obesity. Expand
Distinct Temporal Regulation of RET Isoform Internalization: Roles of Clathrin and AP2
TLDR
The data establish that interactions with the AP2 complex promote RET receptor internalization via clathrin‐mediated endocytosis but that RET9 and RET51 have distinct internalization kinetics that may contribute to differences in their biological functions. Expand
Abstract 4994: RET isoforms differentially contribute to focal adhesion formation
TLDR
The results suggest that RET51 promotes more early and late stage focal adhesion formation than does RET9, and demonstrates that the kinase dead form of RET51 results in a decrease of the number of focal adhesions compared to RET51 wild-type, suggesting that the increase in focalAdhesion formation in the presence of RET 51 is phosphorylation-dependent. Expand
Abstract 4986: Distinct temporal regulation of RET isoform internalization: Roles of clathrin and AP2
TLDR
The data establish that interactions with the AP2 complex promote RET receptor internalization via clathrin-mediated pathways but that RET9 and RET51 have distinct internalization kinetics that may contribute to the functional differences between RET isoforms which are critical to regulating RET's contribution to tumorigenesis and normal development. Expand